Prostaglandin E

Prostaglandin E is a family of naturally occurring prostaglandins and may be used pharmaceutically in medicine.

Types include:

Prostaglandin E₁ also termed Alprostadil

Prostaglandin E₂ also termed Dinoprostone

It is created from prostaglandin E synthase.

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

Prostaglandin E2

Prostaglandin E2 is secreted in microvessels by the endothelium. It is a direct vasodilator and it inhibits the release of noradrenaline from sympathetic nerve terminals. It doesn't have the effect on platelets PGI2 does.

References

↑ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.

Pharmacology 2007. Rang, Dale, Ritter, Flower. Churchill Livingstone Elsevier.

External links

Prostaglandins E at the US National Library of Medicine Medical Subject Headings (MeSH)

This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Prostaglandin_E

Prostaglandin E2

The naturally occurring prostaglandin E2 (PGE2 or PGE₂) is known in medicine as dinoprostone. It has important effects in labour (softening the cervix and causing uterine contraction) and also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts. PGE2 is also the prostaglandin that ultimately induces fever.

PGE2 also suppresses T cell receptor signaling and may play a role in resolution of inflammation.

It is sold under the trade name of Cervidil (by Forest Laboratories, Inc. and Propess (by Ferring Pharmaceuticals). This is a controlled release vaginal insert. Prostin E₂ (by Pfizer Inc.), and Glandin (by Nabiqasim Pharmaceuticals Pakistan) as a vaginal suppository, to prepare the cervix for labour; it is used to induce labour.

Like other prostaglandins, dinoprostone can be used as an abortifacient. It is a direct vasodilator, relaxing smooth muscles, and it inhibits the release of noradrenaline from sympathetic nerve terminals. It does not inhibit platelet aggregation, where PGI2 does.