Promoter (genetics)

In genetics, a promoter is a region of DNA that initiates transcription of a particular gene. Promoters are located near the transcription start sites of genes, on the same strand and upstream on the DNA (towards the 5' region of the sense strand). Promoters can be about 100–1000 base pairs long.

Overview

For transcription to take place, the enzyme that synthesizes RNA, known as RNA polymerase, must attach to the DNA near a gene. Promoters contain specific DNA sequences such as response elements that provide a secure initial binding site for RNA polymerase and for proteins called transcription factors that recruit RNA polymerase. These transcription factors have specific activator or repressor sequences of corresponding nucleotides that attach to specific promoters and regulate gene expression.

Promoters represent critical elements that can work in concert with other regulatory regions (enhancers, silencers, boundary elements/insulators) to direct the level of transcription of a given gene.

Genetics

Genetics is the study of genes, heredity, and genetic variation in living organisms. It is generally considered a field of biology, but it intersects frequently with many of the life sciences and is strongly linked with the study of information systems.

The father of genetics is Gregor Mendel, a late 19th-century scientist and Augustinian friar. Mendel studied 'trait inheritance', patterns in the way traits were handed down from parents to offspring. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene.

Trait inheritance and molecular inheritance mechanisms of genes are still a primary principle of genetics in the 21st century, but modern genetics has expanded beyond inheritance to studying the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance) and within the context of a population. Genetics has given rise to a number of sub-fields including epigenetics and population genetics. Organisms studied within the broad field span the domain of life, including bacteria, plants, animals, and humans.

Genetics (journal)

Genetics is a monthly scientific journal publishing investigations bearing on heredity, genetics, biochemistry and molecular biology. Genetics is published by the Genetics Society of America. It has a delayed open access policy, and makes articles available online without a subscription after 12 months have elapsed since first publication. Since 2010, it is published online-only.George Harrison Shull was the founding editor of Genetics in 1916. Its 2014 impact factor is 5.963.

Editors-in-Chief

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Genetic relationship (linguistics)

In linguistics, genetic relationship is the usual term for the relationship which exists between languages that are members of the same language family. The term genealogical relationship is sometimes used to avoid confusion with the unrelated use of the term in biological genetics. Languages that possess genetic ties with one another belong to the same linguistic grouping, known as a language family. These ties are established through use of the comparative method of linguistic analysis.

Two languages are considered to be genetically related if one is descended from the other or if both are descended from a common ancestor. For example, Italian is descended from Latin. Italian and Latin are therefore said to be genetically related. Spanish is also descended from Latin. Therefore, Spanish and Italian are genetically related. In a similar way, Swedish and Norwegian are genetically related through the North Germanic branch of the Indo-European language family.