Evans Blue (dye)

T-1824 or Evans Blue, often incorrectly rendered as Evan's Blue, is an azo dye which has a very high affinity for serum albumin. Because of this, it can be useful in physiology in estimating the proportion of body water contained in blood plasma.

Evans blue dye has been used as a viability assay on the basis of its penetration into non-viable cells, although the method is subject to error because it assumes that damaged or otherwise altered cells are not capable of repair and therefore are not viable.

Evans blue is also used to assess the permeability of the blood–brain barrier to macromolecules. Because serum albumin cannot cross the barrier, and virtually all Evans Blue is bound to albumin, normally the neural tissue remains unstained. When the BBB has been compromised, albumin-bound Evans blue enters the CNS. It fluoresces with excitation peaks at 470 and 540 nm and an emission peak at 680 nm.

Evans blue is pharmacologically active, acting as a negative allosteric modulator of the AMPA and kainate receptors and as an inhibitor of vesicular glutamate transporters. It also acts on P2 receptors.

Evans Blue

Evans Blue is an alternative rock band from Toronto, Ontario, Canada founded in 2005. Altogether, they have sold over 1 million albums worldwide, including four studio albums and one live album.

History

Origins (2005)

Evans Blue came together in early 2005. Five musicians, then in three separate bands, met through a local musician's message board. Lead singer Kevin Matisyn suggested the name, which refers to the dye that is injected into the bloodstream to measure blood volume, which he had read in one of his medical books. The band then caught the attention of producer Trevor Kustiak (Cool for August) and his partner Mari Dew, of The Pocket Studios. The original lead guitarist, Kevin Smith, left due to personal reasons before the group secured a record label.

They recorded three demo songs, titled "Black Hole", "Saturnalia" and "Starlight", all of which were available on their personal MySpace page. At that time, updates on the bands' progress and prose by former lead singer, Kevin Matisyn were periodically given via the MySpace blogs.

Evans Blue (album)

Evans Blue is the third studio album from Canadian band Evans Blue. It is the first to feature new singer Dan Chandler and the last to feature drummer Howard Davis.

Singles

The first single released from the album was "Sick of It", which was released on their MySpace page before the official release of the single. The second single was "Bulletproof". The third single was "Erase My Scars". The song peaked at #45 on the Rock Songs Chart and is their first charting single since 2007's "The Pursuit". The current single is "Say It", which was released on February 1, 2011.

Track listing

Personnel