Polymerase

A polymerase is an enzyme (EC 2.7.7.6/7/19/48/49) that synthesizes long chains or polymers of nucleic acids. DNA polymerase and RNA polymerase are used to assemble DNA and RNA molecules, respectively, by copying a DNA or RNA template strand using base-pairing interactions.

A polymerase from the thermophilic bacterium, Thermus aquaticus (Taq) (PDB 1BGX, EC 2.7.7.7) is used in the polymerase chain reaction, an important technique of molecular biology.

Other well-known polymerases include:

Terminal Deoxynucleotidyl Transferase (TDT), which lends diversity to antibody heavy chains

Reverse Transcriptase, an enzyme used by RNA retroviruses like HIV, which is used to create a complementary strand to the preexisting strand of viral RNA before it can be integrated into the DNA of the host cell. It is also a major target for antiviral drugs.

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Latest News for: polymerase

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Polymerase Chain Reaction (PCR) Market Revenue Estimated 35.09 (USD Billion) till 2034, Driving Technology, Demands ...

GetNews 10 Mar 2025

"Polymerase Chain Reaction (PCR) Market" ... Polymerase Chain Reaction (PCR) Market Overview ... As per MRFR analysis, the Polymerase Chain Reaction Market Size was estimated at 15.52 (USD Billion) in 2024 ... Polymerase Chain Reaction Market Scope.

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Structural basis of SARS-CoV-2 polymerase inhibition by nonnucleoside inhibitor HeE1-2Tyr

PNAS 04 Mar 2025

The viral replication machinery, the RNA-dependent RNA polymerase (... .

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