Polo kinase
In enzymology, a polo kinase (EC 2.7.11.21) is a kinase enzyme i.e. one that catalyzes the chemical reaction
Thus, the two substrates of these enzymes are ATP and protein, whereas their two products are ADP and phosphoprotein.
These enzymes belong to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases).
The systematic name of this [polo[-like] kinase] enzyme class is ATP:protein phosphotransferase (spindle-pole-dependent).
Examples and other names in common use include Cdc5, Cdc5p, Plk, PLK, Plk1, Plo1, POLO kinase, polo serine-threonine kinase, polo-like kinase, polo-like kinase 1, serine/threonine-specific Drosophila kinase polo, and STK21.
These enzymes participate in 3 metabolic pathways: cell cycle, cell cycle - yeast, and progesterone-mediated oocyte maturation.
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 2OGQ, 2OJS, 2OJX, 2OU7, and 2OWB.
Podcasts:
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by Blacknuss
Last Night A DJ Saved My Life
by: BlacknussLast night a D.J. saved my life
Last night a D.J. saved my life
yeah
'cause I was sittin' there bored to death
And in just one breath he said: You gotta get up
You gotta get off
you gotta get down
girl.
You know
you drive me crazy
baby
You've got me turning to another man.
Called you on the phone
no one's home -
Baby
why'd you leave me all alone?
And if it wasn't for the music I don't know what I do.
Last night a D.J. saved my life
Last night a D.J. saved my life from a broken heart.
Last night a D.J. saved my life
Last night a D.J. saved my life with a song.
You know I hopped into my car - didn't get very far
I know.
Before I had you on my mind - why be so unkind?
You've got your women all around
all around this town.
But I was trapped in love with you and I didn't know what to do
But then I turned on the radio
found out all I need to know.
- Check it out. -
Last night a D.T. saved my life
. . .
Last night a D.J. saved my life
. . .
listen up to your local D.J. - you better hear what he's got to sa
There's not a problem
That I can't fix
'cause I can do
On the double. And
you don't let it
Trouble your brain
'cause away goes trouble
Down the drain. Said
Away goes trouble down
The drain. - Well