Methadone

Methadone, sold under the brand name Dolophine among others, is an opioid used to treat pain and as maintenance therapy or to help with detoxification in people with opioid dependence. Detoxification can either occur relatively rapidly in less than a month or gradually over as long as six months. While a single dose has a rapid effect, maximum effect can take five days of use. The effects last about six hours after a single dose and a day and a half after long-term use. Methadone is taken by mouth or by injection into a muscle or vein.

Side effects are similar to that of other opioids. Commonly these include dizziness, sleepiness, vomiting, and sweating. Serious risks include opioid abuse or a decreased effort to breathe. Heart arrhythmia may also occur including prolonged QT. The number of deaths in the United States involving methadone poisoning was 4,418 in 2011 which was 26% of total deaths from opioid poisoning. Risks are greater with higher doses. Methadone is made by chemical synthesis and acts on opioid receptors.

PHY (disambiguation)

PHY is an abbreviation for the physical layer of the OSI model and refers to the circuitry required to implement physical layer functions.

PHY or Phy may also refer to:

PHY (chip)

PHY is an abbreviation for the physical layer of the OSI model and refers to the circuitry required to implement physical layer functions.

A PHY connects a link layer device (often called MAC as an abbreviation for media access control) to a physical medium such as an optical fiber or copper cable. A PHY device typically includes a Physical Coding Sublayer (PCS) and a Physical Medium Dependent (PMD) layer. The PCS encodes and decodes the data that is transmitted and received. The purpose of the encoding is to make it easier for the receiver to recover the signal.

Example uses