| Phosphodiesterase 6D, cGMP-specific, rod, delta | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 PDB rendering based on 1ksg. |
|||||||||||||
|
|||||||||||||
| Identifiers | |||||||||||||
| Symbols | PDE6D; PDED | ||||||||||||
| External IDs | OMIM: 602676 MGI: 1270843 HomoloGene: 1954 ChEMBL: 3860 GeneCards: PDE6D Gene | ||||||||||||
| EC number | 3.1.4.17 | ||||||||||||
|
|||||||||||||
| RNA expression pattern | |||||||||||||
 |
|||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5147 | 18582 | |||||||||||
| Ensembl | ENSG00000156973 | ENSMUSG00000026239 | |||||||||||
| UniProt | O43924 | O55057 | |||||||||||
| RefSeq (mRNA) | NM_002601.2 | NM_008801.2 | |||||||||||
| RefSeq (protein) | NP_002592.1 | NP_032827.1 | |||||||||||
| Location (UCSC) | Chr 2: 232.6 – 232.65 Mb |
Chr 1: 88.44 – 88.48 Mb |
|||||||||||
| PubMed search | [1] | [2] | |||||||||||
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta is an enzyme that in humans is encoded by the PDE6D gene.[1][2][3]
Interactions [link]
PDE6D has been shown to interact with ARL2,[4][5] RAP1A,[6][5] Rnd1,[6][5] Retinitis pigmentosa GTPase regulator[7] and HRAS.[5][6]
References [link]
- ^ Ershova G, Derre J, Chetelin S, Nancy V, Berger R, Kaplan J, Munnich A, de Gunzburg J (Apr 1998). "cDNA sequence, genomic organization and mapping of PDE6D, the human gene encoding the delta subunit of the cGMP phosphodiesterase of retinal rod cells to chromosome 2q36". Cytogenet Cell Genet 79 (1–2): 139–41. DOI:10.1159/000134701. PMID 9533031.
- ^ Li N, Florio SK, Pettenati MJ, Rao PN, Beavo JA, Baehr W (Jun 1998). "Characterization of human and mouse rod cGMP phosphodiesterase delta subunit (PDE6D) and chromosomal localization of the human gene". Genomics 49 (1): 76–82. DOI:10.1006/geno.1998.5210. PMID 9570951.
- ^ "Entrez Gene: PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5147.
- ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
- ^ a b c d Hanzal-Bayer, Michael; Renault Louis, Roversi Pietro, Wittinghofer Alfred, Hillig Roman C (May. 2002). "The complex of Arl2-GTP and PDEδ: from structure to function". EMBO J. (England) 21 (9): 2095–106. DOI:10.1093/emboj/21.9.2095. ISSN 0261-4189. PMC 125981. PMID 11980706. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125981.
- ^ a b c Nancy, Vanessa; Callebaut Isabelle, El Marjou Ahmed, de Gunzburg Jean (Apr. 2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". J. Biol. Chem. (United States) 277 (17): 15076–84. DOI:10.1074/jbc.M109983200. ISSN 0021-9258. PMID 11786539.
- ^ Linari, M; Ueffing M, Manson F, Wright A, Meitinger T, Becker J (Feb. 1999). "The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (4): 1315–20. DOI:10.1073/pnas.96.4.1315. ISSN 0027-8424. PMC 15460. PMID 9990021. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15460.
Further reading [link]
- Marzesco AM, Galli T, Louvard D, Zahraoui A (1998). "The rod cGMP phosphodiesterase delta subunit dissociates the small GTPase Rab13 from membranes". J. Biol. Chem. 273 (35): 22340–5. DOI:10.1074/jbc.273.35.22340. PMID 9712853.
- Lorenz B, Migliaccio C, Lichtner P, et al. (1998). "Cloning and gene structure of the rod cGMP phosphodiesterase delta subunit gene (PDED) in man and mouse". Eur. J. Hum. Genet. 6 (3): 283–90. DOI:10.1038/sj.ejhg.5200215. PMID 9781033.
- Linari M, Ueffing M, Manson F, et al. (1999). "The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase". Proc. Natl. Acad. Sci. U.S.A. 96 (4): 1315–20. DOI:10.1073/pnas.96.4.1315. PMC 15460. PMID 9990021. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15460.
- Mou H, Grazio HJ, Cook TA, et al. (1999). "cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and delta subunits". J. Biol. Chem. 274 (26): 18813–20. DOI:10.1074/jbc.274.26.18813. PMID 10373499.
- Linari M, Hanzal-Bayer M, Becker J (1999). "The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner". FEBS Lett. 458 (1): 55–9. DOI:10.1016/S0014-5793(99)01117-5. PMID 10518933.
- Nancy V, Callebaut I, El Marjou A, de Gunzburg J (2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". J. Biol. Chem. 277 (17): 15076–84. DOI:10.1074/jbc.M109983200. PMID 11786539.
- Hanzal-Bayer M, Renault L, Roversi P, et al. (2002). "The complex of Arl2-GTP and PDEδ: from structure to function". EMBO J. 21 (9): 2095–106. DOI:10.1093/emboj/21.9.2095. PMC 125981. PMID 11980706. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125981.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. DOI:10.1016/j.cell.2005.08.029. PMID 16169070.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
- Wilson SJ, Smyth EM (2006). "Internalization and recycling of the human prostacyclin receptor is modulated through its isoprenylation-dependent interaction with the delta subunit of cGMP phosphodiesterase 6". J. Biol. Chem. 281 (17): 11780–6. DOI:10.1074/jbc.M513110200. PMID 16527812.
|
||||||||||||
 |
This article on a gene on chromosome 2 is a stub. You can help Wikipedia by expanding it. |
https://wn.com/PDE6D
Podcasts:
PLAYLIST TIME:
-
by Pothead
-
by Pothead
-
by Pothead
-
by Pothead
-
by Pothead
-
by Pothead
-
by Pothead
-
by Pothead
-
by Pothead
-
by Pothead
-
by Pothead
-
by Pothead
-
by Pothead
-
by Pothead
-
by Pothead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Bedhead
-
by Pie Todd
-
by Pete Teo
-
by Pete Teo
Twisted Tomato
by: PotheadThe ppython is waiting,we take it
A twisted tomato,forsaken
"What's got into me?What's got into you?
We're naked."
(Everybody's gonna say it)
Mama says to me,mama says to me,
(Homeless made us find our glory)
Mama said,"No more."
Finding our way like a teen here in space
Disembrace what we always remember
It don't cost a dime if you're lucky in time
So you might as well make this all something
The garbage,this music,what I feel
Well listen what we do,where we've been
We got into see,we get in to do,
We're taken aback
(Everybody's gonna say it)
Mama said to me,mama said to me,
(Homeless made us find glory)
Mama said,"It's good."
Finding our way like a teen here in space
Disembrace what we always remember
It don't cost a dime 'cause we're lucky in time
So we might as well make this all something
Findin' out!
Finding our place like a teen here in space
Disembrace what we always remember
It don't cost a dime 'cause we're lucky in time
So you might as well make this all something
We're various traits of a thousand and one
Generations we'll never remember
It's only as if you could never believe
That by chance you couldn't even be here
Bring it back,bring it back
What you said,what you said
Mama said to me,mama said to me
Mama said to me,"Good."
Mama said to me,mama said to me