Piccolo (presynaptic cytomatrix protein)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1UJD
Identifiers
Symbols	PCLO; ACZ
External IDs	OMIM: 604918 MGI: 1349390 HomoloGene: 69111 GeneCards: PCLO Gene
Gene Ontology Molecular function • transporter activity • calcium ion binding • profilin binding • calcium-dependent phospholipid binding Cellular component • cytoskeleton • synaptic vesicle • membrane • cell junction • synapse Biological process • cytoskeleton organization • synaptic vesicle exocytosis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27445	26875
Ensembl	ENSG00000186472	ENSMUSG00000061601
UniProt	Q9Y6V0	Q9QYX7
RefSeq (mRNA)	NM_014510.2	NM_001110796.1
RefSeq (protein)	NP_055325.2	NP_001104266.1
Location (UCSC)	Chr 7: 82.38 – 82.79 Mb	Chr 5: 14.51 – 14.86 Mb
PubMed search	[1]	[2]
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Protein piccolo is a protein that in humans is encoded by the PCLO gene.^[1][2][3]

Synaptic vesicles dock and fuse in the active zone of the plasma membrane at chemical synapses. The presynaptic cytoskeletal matrix (PCM), which is associated with the active zone and is situated between synaptic vesicles, is thought to be involved in maintaining the neurotransmitter release site in register with the postsynaptic reception apparatus. The cycling of synaptic vesicles is a multistep process involving a number of proteins (see MIM 603215). Among the components of the PCM that orchestrate these events are Bassoon (BSN; MIM 604020), RIM (RIMS1; MIM 606629), Oboe (RIMS2; MIM 606630), and Piccolo (PCLO).[supplied by OMIM]^[3]

Interactions [link]

PCLO has been shown to interact with GIT1.^[4]

Clinical relevance [link]

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.^[5]

References [link]

Further reading [link]

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