Paraxial mesoderm
Paraxial mesoderm, also known as presomitic or somitic mesoderm is the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites, blocks of tissue running along both sides of the neural tube, which form muscle and the tissues of the back, including connective tissue and the dermis.
Formation and somitogenesis
The paraxial and other regions of the mesoderm are thought to be specified by bone morphogenetic proteins, or BMPs, along an axis spanning from the center to the sides of the body. Members of the FGF family also play an important role, as does the WNT pathway. In particular, Noggin, a downstream target of the Wnt pathway, antagonizes BMP signaling, forming boundaries where antagonists meet and limiting this signaling to a particular region of the mesoderm. Together, these pathways provide the initial specification of the paraxial mesoderm and maintain this identity.
This specification process has now been fully recapitulated in vitro with the formation of paraxial mesoderm progenitors from pluripotent stem cells, using a directed differentiation approach.
