Para

Para may refer to:

Miscellaneous

Sports

Paraú

Paraú is a municipality in the state of Rio Grande do Norte in the Northeast region of Brazil.

See also

References

Coordinates: 5°47′S 37°06′W / 5.783°S 37.100°W / -5.783; -37.100

Paraí

Paraí is a municipality in the state Rio Grande do Sul, Brazil.

See also

Coordinates: 28°35′38″S 51°47′09″W / 28.59389°S 51.78583°W / -28.59389; -51.78583

SUR

Sur may refer to:

Acronym

SUR may refer to:

In music, film and other media

Sur (tango)

Sur is a tango with music by Aníbal Troilo and lyrics by Homero Manzi. It was first recorded by Troilo's orchestra with vocals by Edmundo Rivero on 23 February 1948. The first live performance, by the same artists, was at the Tibidabo night club in Buenos Aires.

Lyrics

The song is an elegy for a lost love, framed in the landmarks of the South side of Buenos Aires, lamenting both the end of a love story and the changes in the barrio. The male narrator addresses the girl in the second person; it is mentioned that the girl was 20 at the time.

Among the landmarks mentioned are: the corner of San Juan and Boedo at the center of the Boedo neighborhood, Pompeya (located directly to the South of Boedo), the railway crossing and the swampland at the (southern) edge of Pompeya, and the enigmatic "blacksmith's corner, mud and pampa", which could refer to the corner of Centenera and Tabaré, already named in Manzi's earlier "Manoblanca" or to a blacksmith shop in the corner of Inclán and Loria, in Parque Patricios neighbourhood.

Sulfonylurea receptor

In the field of molecular biology, the sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels K_ir6.x (6.1 and 6.2). The association of four K_ir6.x and four SUR subunits form an ion conducting channel commonly referred to as the K_ATP channel.

There are three forms of the sulfonylurea receptor, SUR1 encoded by the ABCC8 gene and SUR2A and SUR2B which are splice variants arising from a single ABCC9 gene.

Function

The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated K_ir6.x potassium channel. Hence the K_ATP channel monitors the energy balance within the cell.

Depending on the tissue in which the K_ATP channel is expressed, altering the membrane potential can trigger a variety of down stream events. For example, in pancreatic beta cells, high levels of glucose lead to increased production of ATP which in turn binds to the K_ATP channel resulting in channel closure. The increase in membrane potential in turn opens voltage-dependent calcium channels increasing intracellular calcium concentrations which triggers exocytosis of insulin.