Pannus is an abnormal layer of fibrovascular tissue or granulation tissue. Common sites for pannus formation include over the cornea, over a joint surface (as seen in rheumatoid arthritis), or on a prosthetic heart valve. Pannus may grow in a tumor-like fashion, as in joints where it may erode articular cartilage and bone.
The term pannus is often used incorrectly to refer to a panniculus (a hanging flap of tissue).
The term "pannus" is derived from the Latin for "cloth". Inflammation and exuberant proliferation of the synovium leads to formation of pannus and destruction of cartilage, bone, tendons, ligaments, and blood vessels. Basically, the hypertrophied synovium is called pannus. Pannus tissue is composed of aggressive macrophage- and fibroblast-like mesenchymal cells, macrophage-like cells and other inflammatory cells that release collagenolytic enzymes.
In people suffering from rheumatoid arthritis, pannus tissue eventually forms in the joint affected by the disease, causing loss of bone and cartilage. From Autoimmunity and Disease by Harley Y. Tse and Michail K. Shaw:
Responsibility is a foreign word to me
it's time to buckle down
time to stand your ground
set any way of life for which you abide by
while not always the ways you would take
set them before you make a mistake
open your eyes and see
I've got too much fun ahead of me
I've got too much fun ahead of me
reality doesn't, it doesn't refer to me
the real worlds no big deal
what's real is what you feel
so tell me now buddy: what are you gonna do?
Will you take advice from me?
Will you be who you wanna be?
You could be going down along ways before me
I've got too much fun ahead of me
I've got too much fun ahead of me
reality doesn't, it doesn't refer to me
the real worlds no big deal, what's real is what you feel
so tell me now buddy: what are you gonna do?
Will you take advice from me?
Will you be who you wanna be?
You could be going down along ways before me
I've got too much fun ahead of me