Blood type

A blood type (also called a blood group) is a classification of blood based on the presence or absence of inherited antigenic substances on the surface of red blood cells (RBCs). These antigens may be proteins, carbohydrates, glycoproteins, or glycolipids, depending on the blood group system. Some of these antigens are also present on the surface of other types of cells of various tissues. Several of these red blood cell surface antigens can stem from one allele (or an alternative version of a gene) and collectively form a blood group system. Blood types are inherited and represent contributions from both parents. A total of 35 human blood group systems are now recognized by the International Society of Blood Transfusion (ISBT). The two most important ones are ABO and the RhD antigen; they determine someone's blood type (A, B, AB and O, with +, − or Null denoting RhD status).

Many pregnant women carry a fetus with a blood type which is different from their own, which is not a problem. What can matter is whether the baby is RhD positive or negative. Mothers who are RhD- and carry a RhD+ baby can form antibodies against fetal RBCs. Sometimes these maternal antibodies are IgG, a small immunoglobulin, which can cross the placenta and cause hemolysis of fetal RBCs, which in turn can lead to hemolytic disease of the newborn called erythroblastosis fetalis, an illness of low fetal blood counts that ranges from mild to severe. Sometimes this is lethal for the fetus; in these cases it is called hydrops fetalis.

Type O Negative

Type O Negative was an American gothic/doom metal band formed in Brooklyn, New York City in 1989. Their lyrical emphasis on themes of romance, depression, and death resulted in the nickname "The Drab Four" (in homage to The Beatles' "Fab Four" moniker). The band went Platinum with 1993's Bloody Kisses, and Gold with 1996's October Rust, and gained a fanbase through seven studio albums, two best-of compilations, and concert DVDs.

On April 14, 2010, lead vocalist, bassist, and principal songwriter Peter Steele died, reportedly from heart failure brought on by an aortic aneurysm. Members Kenny Hickey and Johnny Kelly stated in a November 2010 interview with French music magazine Rock Hard that the band would not continue.

History

Origins (1980s–1991)

Former Carnivore frontman Steele, along with childhood friends Sal Abruscato (later replaced by Johnny Kelly), Josh Silver and Kenny Hickey, formed Type O Negative and signed to Roadrunner Records. Shortly after signing in 1991 the band released their debut, Slow, Deep and Hard.