Pai

Pai or PAI may refer to:

People

Fictional characters

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Other uses

Acronyms

Plasminogen activator inhibitor-1

Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor or serpin E1 is a protein that in humans is encoded by the SERPINE1 gene. Elevated PAI-1 is a risk factor for thrombosis and atherosclerosis

PAI-1 is a serine protease inhibitor (serpin) that functions as the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological breakdown of blood clots). It is a serine protease inhibitor (serpin) protein (SERPINE1).

The other PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by the placenta and only present in significant amounts during pregnancy. In addition, protease nexin acts as an inhibitor of tPA and urokinase. PAI-1, however, is the main inhibitor of the plasminogen activators.

Genetics

The PAI-1 gene is SERPINE1, located on chromosome 7 (7q21.3-q22). There is a common polymorphism known as 4G/5G in the promoter region. The 5G allele is slightly less transcriptionally active than the 4G.

Plasminogen activator inhibitor-2

Plasminogen activator inhibitor-2 (placental PAI) is a coagulation factor that inactivates tPA and urokinase. It is present in most cells, especially monocytes/macrophages. PAI-2 exists in two forms, a 60-kDa extracellular glycosylated form and a 43-kDa intracellular form.

It is present only at detectable quantities in blood during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosis during pregnancy. The majority of expressed PAI-2 remains unsecreted due to the presence of an inefficient internal signal peptide.

Interactions

Plasminogen activator inhibitor-2 (SerpinB2) has been reported to bind a series of intracellular and extracellular proteins. Whether SerpinB2's physiological function is inhibition of the extracellular protease urokinase and/or whether SerpinB2 has intracellular activities remains controversial. At least one of SerpinB2's physiological functions may involve regulation of adaptive immunity.

Lom

Lom or LOM may refer to:

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Abbreviations

Lom (album)

Lom (English: Rumpus) is the sixth studio album by Bosnian-Serbian pop-folk recording artist Seka Aleksić. It was released 2 May 2012 through the record label Grand Production.

Track listing

References

Lom (river)

Coordinates: 43°37′17″N 22°50′54″E / 43.62139°N 22.84833°E / 43.62139; 22.84833

The Lom (Bulgarian: Лом, Latin: Almus) is a river in northwestern Bulgaria, a right tributary of the Danube flowing into it 1 km east of the town of Lom.

The river takes its source from the foot of Midzhur (2,168 m), the highest peak of western Stara Planina, on the Bulgarian-Serbian border, and mainly flows northeast until its upper course, where it heads north. It passes the villages of Gorni Lom, Dolni Lom, Sredogriv, Falkovets, Ruzhintsi, Drazhintsi, Belo Pole, Roglets, Drenovets, Topolovets, Knyazheva Mahala, Kriva Bara, Vasilovtsi, Staliyska Mahala, Traykovo, as well as three quarters of the town of Lom: Momin Brod, Dalgoshevtsi and Golintsi.

Chinú

Chinú is a town and municipality located in the Córdoba Department, northern Colombia.

References

Coordinates: 9°05′N 75°20′W / 9.083°N 75.333°W / 9.083; -75.333