PTPRE
Receptor-type tyrosine-protein phosphatase epsilon is an enzyme that in humans is encoded by the PTPRE gene.
Function
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels.
Interactions
Podcasts:
-
by Pedobear
-
by Pedobear
The Pedobear
by: PedobearNow this is a story all about how
My life got flipped turned upside down
So I'd like to take a minute - just sit right there
lemmie tell you how I became the meme called Pedobear.
In West Neverland, born and raised
Stalking playgrounds is how I spent most of my days
Checking out maxing, relaxing all cool
Playing with my balls near the kids pool
When a couple kids who were looking real good
Didn't check the registry in their neighborhood
I touched one little kid and her mom got scared
She said "I'm calling the FBI you sick Pedobear!"
So I whistled for a van but when it came near
The license plate said Chan and there was a party in the
rear
If anything I thought this van was a snare
Ah, forget it you can't catch Pedobear!
I pulled out of this girl who was 7 or 8
Yelled to the Moralfags "Yo Homos! Sage you later!"
Looked at her crotch, got there before hair