PTPRD
Receptor-type tyrosine-protein phosphatase delta is an enzyme that in humans is encoded by the PTPRD gene.
Function
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chick and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple tissue specific alternatively spliced transcript variants of this gene have been reported.
Clinical significance
Mutations in the PTPRD gene are associated with autism,obsessive–compulsive disorder, and breast cancer.
Podcasts:
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by Mary-Kate And Ashley Olsen
Piata Party
by: Mary-Kate And Ashley OlsenJust like the kids in Mexico.
We'll have a real fun party ya know.
We'll wear the colors of the rainbow.
And listen to the trumpets blow.
Chorus:
I wanna go to a Pinata Party.
Party Hearty.
Sing and dance at a Pinata Party.
Till they tell us to go home.
We can sit here if you prefer.
But I'm a bit of an adventurer.
So help me move aside the furniture.
Hey everybody, grab a partner.
We can do the tango, or a few pirouettes.
Or we can do the Fan Dango,
as long as we've got castanets.
Chorus
And then it's time for the Pinata.
Swinging high like it oughta.
We'll have the whole enchilada
when the stick hits Pinata.
It's to be a sunny day,
when it breaks in two.
A honey of a sunny day,
raining goodies down on you.
Chorus (2 X)
La la la, la la la, la la la,
till they tell us to go home.
La la la, la la la, la la la,
Till they tell us to go home.
Go home!