PTPRC
Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the PTPRC gene. PTPRC is also known as CD45 antigen (CD stands for cluster of differentiation), which was originally called leukocyte common antigen (LCA).
Function
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and, thus, functions as a negative regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
Podcasts:
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by Redman
Boodah Break
by: RedmanYo.. YO! YO!!!!!!!!!!Hah
If you got your motherfuckin lighters
Light em up, light em up, light em up, light em up (D that's me!)
We gonna take this time out, to smoke a blunt
Ha hah, all you buddha smokers, roll it up, roll it up
(D that's me!)
[sample from Public Enemy of Chuck D]
If y'all really like to rock the funky beats
Somebody in the house say 'Hell yeah'.. "HELL YEAH!"
Yo, I like that from the people up top
Check this out
[RedMan]
Yo, check the newsflash
Grab the mic, buck until my neck gets whiplash
My Lethal Weapon tongue need a gun permit badge
Mastermind any flow that can shine
Doc walk the blocks like either your ass or mine
Jersey style for dead presidents
I'll whoop your ass with one leg, Kirby style, for thirty miles
Shut the Fawcett to Farah
Drain the Panama Canal up, that'll run like mascara
I put it all like friends at Don Pooh party
Before Mr. T, my jewels was too gaudy
My foul mouth turn a New York crowd out
Reach out and touch and use nine to dial out
So Brick City are you ready, ready
So D.C. are you ready...Yo cheers to the underground, Doc's Da Name
Rap is like the NBA, I love this game
[outro]
Yo yo, to all my niggas and bitches
across the ghetto United States
If you high as hell riding in your car
Honk your horns, and light it up
Light it up, light it up yo, light it up
Ha hah, signin off truly yours