PTPRB

Receptor-type tyrosine-protein phosphatase beta or VE-PTP is an enzyme specifically expressed in endothelial cells that in humans is encoded by the PTPRB gene.

Function

VEPTP is a member of the classical protein tyrosine phosphatase (PTP) family. The deletion of the gene in mouse models was shown to be emryonically lethal, thus indicating that it is important for vasculogenesis and blood vessel development. In addition it was shown to participate in adherens junctions and regulate vascular permeability.

Interactions

VE-PTP contains an extracellular domain composed of multiple fibronectin type_III repeats, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to R3 receptor subtype PTPs. The extracellular region was shown to interact with the angiopoietin receptor Tie-2. and with the adhesion protein VE-cadherin.

VE-PTP was also found to interact with Grb2 and plakoglobin through its cytoplasmatic domain.

References

Further reading