PTPRA
Receptor-type tyrosine-protein phosphatase alpha is an enzyme that in humans is encoded by the PTPRA gene.
Function
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.
Interactions
PTPRA has been shown to interact with Grb2 and KCNA2.
References
Further reading
Podcasts:
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by Pedobear
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by Pedobear
The Pedobear
by: PedobearNow this is a story all about how
My life got flipped turned upside down
So I'd like to take a minute - just sit right there
lemmie tell you how I became the meme called Pedobear.
In West Neverland, born and raised
Stalking playgrounds is how I spent most of my days
Checking out maxing, relaxing all cool
Playing with my balls near the kids pool
When a couple kids who were looking real good
Didn't check the registry in their neighborhood
I touched one little kid and her mom got scared
She said "I'm calling the FBI you sick Pedobear!"
So I whistled for a van but when it came near
The license plate said Chan and there was a party in the
rear
If anything I thought this van was a snare
Ah, forget it you can't catch Pedobear!
I pulled out of this girl who was 7 or 8
Yelled to the Moralfags "Yo Homos! Sage you later!"
Looked at her crotch, got there before hair