Parathyroid hormone 1 receptor
Parathyroid hormone/parathyroid hormone-related peptide receptor also known as parathyroid hormone 1 receptor (PTH1R) is a protein that in humans is encoded by the PTH1R gene. PTH1R functions as a receptor for parathyroid hormone (PTH) and for parathyroid hormone-related protein (PTHrP), also called parathyroid hormone-like hormone (PTHLH).
Function
This "classical" PTH receptor is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C. In bone, it is expressed on the surface of osteoblasts. When the receptor is activated through PTH binding, osteoblasts express RANKL (Receptor Activator of Nuclear Factor kB Ligand), which binds to RANK (Receptor Activator of Nuclear Factor kB) on osteoclasts. This turns on osteoclasts to ultimately increase the resorption rate.
Mechanism
It is a member of the secretin family of G protein-coupled receptors. The activity of this receptor is mediated by Gs G proteins which activate adenylyl cyclase. Besides, they also activate phosphatidylinositol-calcium second messenger system.
Podcasts:
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Be With You
by: Neil YoungCrossin' the river in a big old boat,
With a dollar bill in my hand.
Gonna go fishin' in the afternoon,
Got a simple plan.
Oh yeah, baby.
I got to hold on,
I got to be strong,
I got to live long,
And be with you.
Lonely nights and lonely days,
When I'm not with you.
Learned to trust and I learned to give,
Found a love that's true.
Oh yeah, baby.
I got to hold on,
I got to be strong,
I got to live long,
And be with you.
Girl it shouldn't be too hard,
To live with you.
It's really not complicated,
Until I get the blues.
Come on over and sit right down,
Let me take your hand,
I got a love gonna fill you up,
Take you to the promised land.
Oh yeah, baby, oh yeah.
I got to hold on,
I got to be strong,
I got to live long,
And be with you.
Be with you baby,
Be with you baby,
I got to be with you babe.
Be with you baby, oh alright.
Lonely nights, lonely days,
When I'm not with you babe.
Learned to trust and I learned to give,
Found a love that's true, babe.
Oh yeah, baby.
I got to hold on now,
Got to be strong now,
To be with you.
Be with you baby,