Protest the Hero

Protest the Hero is a Canadian progressive metal band from Whitby, Ontario. Originally named Happy Go Lucky, the band changed their name to Protest the Hero shortly before releasing their debut EP, Search for the Truth, in 2002. In 2005, the band released their first full-length album Kezia on the indie label Underground Operations.

On January 23, 2006, the band signed with Vagrant Records for Kezia's American release on April 4, 2006. Their second full-length album, Fortress was released by Underground Operations in Canada and by Vagrant Records worldwide on January 29, 2008. The band released their third studio album, Scurrilous, on March 22, 2011.

Expressing frustrations with record labels, in January of 2013 the band announced that they would crowdfund their fourth full-length album. The Indiegogo campaign was a runaway success, and the independently-released Volition debuted on October 29, 2013, distributed with the help of Razor & Tie. In October of 2015, the band announced that their fifth release would take the form of a subscription service using Bandcamp entitled Pacific Myth.

PTH

PTH may refer to:

Parathyroid hormone

Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide containing 84 amino acids, yet effective hormone-receptor interaction requires solely the 34-N-terminal amino acids. While PTH acts to increase the concentration of ionic calcium (Ca²⁺) in the blood, calcitonin, a hormone produced by the parafollicular cells (C cells) of the thyroid gland, acts to decrease ionic calcium concentration. PTH essentially acts to increase the concentration of calcium in the blood by acting upon the parathyroid hormone 1 receptor, which is present at high levels in bone and kidney, and the parathyroid hormone 2 receptor, which is present at high levels in the central nervous system, pancreas, testis, and placenta. PTH half-life is approximately 4 minutes. It has a molecular mass of approximately 9500 Da.

Structure

hPTH-(1-34) crystallizes as a slightly bent, long helical dimer. Analysis reveals that the extended helical conformation of hPTH-(1-34) is the likely bioactive conformation. The N-terminal fragment 1-34 of parathyroid hormone (PTH) has been crystallized and the structure has been refined to 0.9 Å resolution.