Prostaglandin DP2 receptor

Prostaglandin D₂ receptor 2 (DP₂) is a human protein encoded by the PTGDR2 gene. DP₂ has also been designated as CD294 (cluster of differentiation 294).

Function

G protein-coupled receptors (GPCRs), such as DP₂, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM]

DP₂ has recently been found when activated by elevated level of prostaglandin D₂ (PGD₂), it could inhibit hair growth. This suggests the DP₂ pathway as a potential target for bald treatment. A particularly promising compound for blocking the DP₂ pathway is a compound known as TM30089, which exhibits a "functional insurmountability" of PGD2 expression.

Ligands

Agonists

Antagonists

Prostaglandin DP1 receptor

Prostaglandin D₂ receptor 1 (DP₁) is a G protein-coupled receptor, encoded by the PTGDR1 gene, for prostaglandin D₂ (PGD₂).

Mechanism

DP₁ is a G protein-coupled receptor (GPCR). Its activity is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca²⁺.

Function

Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D₂, functions as a mast cell-derived mediator to trigger asthmatic responses. It also causes vasodilation

Ligands

See also

References

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Prostaglandin D2 receptor

The prostaglandin D₂ (PGD₂) receptors are G protein-coupled receptors that bind and are activated by prostaglandin D₂. They include the following proteins:

See also

References

External links