PSMD4
26S proteasome non-ATPase regulatory subunit 4, also as known as 26S Proteasome Regulatory Subunit Rpn10 (systematic nomenclature), is an enzyme that in humans is encoded by the PSMD4 gene. This protein is one of the 19 essential subunits that contributes to the complete assembly of 19S proteasome complex.
Gene
The gene PSMD4 encodes one of the non-ATPase subunits of the 19S regulator base, subunit Rpn10. Pseudogenes have been identified on chromosomes 10 and 21. The human PSMD4 gene has 10 exons and locates at chromosome band 1q21.3.
Protein
The human protein 26S proteasome non-ATPase regulatory subunit 4 is 41 kDa in size and composed of 377 amino acids. The calculated theoretical pI of this protein is 4.68. An alternative splicing during gene expression generates an isoform of the protein in which the amino acid sequence from 269-377 is missing while the amino sequence between 255-268 is replaced from DSDDALLKMTISQQ to GERGGIRSPGTAGC.
Complex assembly
Podcasts:
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by Carman
Some - O - Dat
by: CarmanWell I got this friend named T.J. Clyde
Who sees this strength of God inside
So he says to me, "Hey, I want Some-O-Dat"
I say Clyde it's easy as one, two, three
You just say this simple prayer with me
He said, "Not me Bubba, but I still want Some-O-Dat"
OOh Some-O-Dat
Well I was sharing with this sales man Lyle
So he says with a million dollar smile
"Why that's interesting you know. Hey I'd like Some-O-Dat."
I said "Lyle you're gonna have to humble your pride and ask the Lord to come inside."
He said, "No-ho-ho-ho, but I still want Some-O-Dat."
Ooh Some-O-Dat
Well you can't find it
In astrology
That horoscope that you read is just a waste
You can't find it looking at the stars
Jupiter, the moon and Mars.
Cause you'll soon find that all you got was space.
Well my best friends Ray has got this niece
That sees within my eyes this peace
And yesterday she said
"I want Some-O-Dat"
Well I said "Hey Sugar, Now it's a breeze
Just talk with Jesus on your knees
She said, "I'm not the type but I still want Some-O-Dat"
Ooh they all want Some-O-Dat
Brother you can't find it
In a bottle
Or even when you pop a pill or two
You can't find it smoking dope or weed
Cause one fine day you're gonna see
That the dope that's being smoked my friend is you
Well if you're depressed
Then get used to it
Cause without Jesus
You have blew it
He's the only one who can give you Some-O-Dat
Why not try the Lord for goodness sake
You'll be happy as a dog with a T-bone steak