Proteasome subunit alpha type-6 is a protein that in humans is encoded by the PSMA6 gene. This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex.
The gene PMSA6 encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome. The gene has 8 exons and locates at chromosome band 14q13. The human protein proteasome subunit alpha type-6 is also known as 20S proteasome subunit alpha-1 (based on systematic nomenclature). The protein is 27 kDa in size and composed of 246 amino acids. The calculated theoretical pI (isoelectric point) of this protein is 6.35.
The proteasome is a multicatalytic proteinase complex with a highly ordered 20S core structure. This barrel-shaped core structure is composed of 4 axially stacked rings of 28 non-identical subunits: the two end rings are each formed by 7 alpha subunits, and the two central rings are each formed by 7 beta subunits. Three beta subunits (beta1, beta2, and beta5) each contains a proteolytic active site and has distinct substrate preferences. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.
you don't get to tell your heart how to feel
it does what it wants when it wants to
all that you can do is pray that it lands in the hands of somebody true!
and you don't get to tell your heart where to stay
no it will not obey cause it knows the truth
let's not confuse it! you try to prove it wrong
but the heart has a mind of its own
chorus:
you can't run from the place that you belong
cause if you run, you'll be feeling so alone
before you know, you'll be picking up the phone
cause the heart has a mind of its own!
can't fight that burning in your chest
you can't fight, feeling such a mess
your hear decides, but it's you that second guest
cause the heart has a mind of its own!
you don't get to fall at the perfect time
for someone love is ending, for someone else is just beginning
someone is gotta cry, someone needs to know why
but the heart tells no lies!
and you don't get to tell your heart when it heels
when it breaks like rock through shatter glass
all you can ask is that the pain moves fast
one day this too, shall last!
by know i hope you know, it has a mind of its own!
chorus:
you can't run from the place that you belong
cause if you run, you'll be feeling so alone
before you know, you'll be picking up the phone
cause the heart has a mind of its own!
can't fight that burning in your chest
you can't fight, feeling such a mess
your hear decides, but it's you that second guest
cause the heart has a mind of its own!
it's so real, can't you see it?
is the heart that really means it
and the heart won't let you lie,
it won't let love be defeated!
sometimes is inconvenient,
but the real truth is you need it
cause the mind will leave you lonely
chorus:
you can't run from the place that you belong
cause if you run, you'll be feeling so alone
before you know, you'll be picking up the phone
cause the heart has a mind of its own!
can't fight that burning in your chest
you can't fight, feeling such a mess
your hear decides, but it's you that second guest