Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene.[1][2][3]
The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.[3]
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Interactions [link]
PRPF6 has been shown to interact with TXNL4B,[4] ARAF[5][6] and Androgen receptor.[7]
References [link]
- ^ Nishikimi A, Mukai J, Kioka N, Yamada M (January 2000). "A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors". Biochim Biophys Acta 1435 (1-2): 147–52. PMID 10561546.
- ^ Makarov EM, Makarova OV, Achsel T, Luhrmann R (June 2000). "The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions". J Mol Biol 298 (4): 567–75. DOI:10.1006/jmbi.2000.3685. PMID 10788320.
- ^ a b "Entrez Gene: PRPF6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=24148.
- ^ Sun, Xiaojing; Zhang Hua, Wang Dan, Ma Dalong, Shen Yan, Shang Yongfeng (July 2004). "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression". J. Biol. Chem. (United States) 279 (31): 32839–47. DOI:10.1074/jbc.M402522200. ISSN 0021-9258. PMID 15161931.
- ^ Yuryev, Anton; Wennogle Lawrence P (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics (United States) 81 (2): 112–25. DOI:10.1016/S0888-7543(02)00008-3. ISSN 0888-7543. PMID 12620389.
- ^ Yuryev, A; Ono M, Goff S A, Macaluso F, Wennogle L P (July 2000). "Isoform-specific localization of A-RAF in mitochondria". Mol. Cell. Biol. (UNITED STATES) 20 (13): 4870–8. DOI:10.1128/MCB.20.13.4870-4878.2000. ISSN 0270-7306. PMC 85938. PMID 10848612. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85938.
- ^ Zhao, Yue; Goto Kiminobu, Saitoh Masayuki, Yanase Toshihiko, Nomura Masatoshi, Okabe Taijiro, Takayanagi Ryoichi, Nawata Hajime (August 2002). "Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor". J. Biol. Chem. (United States) 277 (33): 30031–9. DOI:10.1074/jbc.M203811200. ISSN 0021-9258. PMID 12039962.
Further reading [link]
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Yuryev A, Ono M, Goff SA, et al. (2000). "Isoform-specific localization of A-RAF in mitochondria.". Mol. Cell. Biol. 20 (13): 4870–8. DOI:10.1128/MCB.20.13.4870-4878.2000. PMC 85938. PMID 10848612. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85938.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. DOI:10.1038/414865a. PMID 11780052.
- Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA 8 (4): 426–39. DOI:10.1017/S1355838202021088. PMC 1370266. PMID 11991638. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1370266.
- Zhao Y, Goto K, Saitoh M, et al. (2002). "Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor.". J. Biol. Chem. 277 (33): 30031–9. DOI:10.1074/jbc.M203811200. PMID 12039962.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis.". Genomics 81 (2): 112–25. DOI:10.1016/S0888-7543(02)00008-3. PMID 12620389.
- Goto K, Zhao Y, Saito M, et al. (2003). "Activation function-1 domain of androgen receptor contributes to the interaction between two distinct subnuclear compartments.". J. Steroid Biochem. Mol. Biol. 85 (2-5): 201–8. DOI:10.1016/S0960-0760(03)00196-1. PMID 12943705.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.". RNA 10 (6): 929–41. DOI:10.1261/rna.7320604. PMC 1370585. PMID 15146077. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1370585.
- Sun X, Zhang H, Wang D, et al. (2004). "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression.". J. Biol. Chem. 279 (31): 32839–47. DOI:10.1074/jbc.M402522200. PMID 15161931.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. DOI:10.1101/gr.2435604. PMC 515316. PMID 15342556. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515316.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Laggerbauer B, Liu S, Makarov E, et al. (2005). "The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation.". RNA 11 (5): 598–608. DOI:10.1261/rna.2300805. PMC 1370748. PMID 15840814. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1370748.
- Batsché E, Yaniv M, Muchardt C (2006). "The human SWI/SNF subunit Brm is a regulator of alternative splicing.". Nat. Struct. Mol. Biol. 13 (1): 22–9. DOI:10.1038/nsmb1030. PMID 16341228.
- Fan S, Goto K, Chen G, et al. (2006). "Identification of the functional domains of ANT-1, a novel coactivator of the androgen receptor.". Biochem. Biophys. Res. Commun. 341 (1): 192–201. DOI:10.1016/j.bbrc.2005.12.167. PMID 16414017.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. DOI:10.1038/msb4100134. PMC 1847948. PMID 17353931. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
External links [link]
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