Protein arginine methyltransferase 5

Protein arginine N-methyltransferase 5 is an enzyme that in humans is encoded by the PRMT5 gene.

Model organisms

Model organisms have been used in the study of PRMT5 function. A conditional knockout mouse line, called Prmt5^{tm2a(EUCOMM)Wtsi} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on mutant mice and two significant abnormalities were observed. No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice but no further abnormalities were observed.