PRL
PRL may refer to:
Prolactin
Prolactin (PRL), also known as luteotropic hormone or luteotropin, is a protein that in humans is best known for its role in enabling mammals, usually females, to produce milk; however, it is influential over a large number of functions with over 300 separate actions of PRL having been reported in various vertebrates. Prolactin is secreted from the pituitary gland in response to eating, mating, estrogen treatment, ovulation, and nursing. Prolactin is secreted in a pulsatile fashion in between these events. Prolactin also plays an essential role in metabolism, regulation of the immune system, and pancreatic development.
Discovered in non-human animals around 1930 by Oscar Riddle at Cold Spring Harbor Laboratory on Long Island, New York, and confirmed in humans in 1970 by Henry Friesen prolactin is a peptide hormone, encoded by the PRL gene.
Although often associated with human milk production, prolactin plays a wide range of other roles in both humans and other vertebrates. (For example, in fish—the oldest known vertebrates—an important function is probably related to control of water and salt balance.) Prolactin also acts in a cytokine-like manner and as an important regulator of the immune system. It has important cell cycle related functions as a growth-, differentiating- and anti-apoptotic factor. As a growth factor, binding to cytokine like receptors, it also has profound influence on hematopoiesis, angiogenesis and is involved in the regulation of blood clotting through several pathways. The hormone acts in endocrine, autocrine, and paracrine manner through the prolactin receptor and a large number of cytokine receptors.
PRL-8-53
PRL-8-53 is a nootropic research chemical derived from benzoic acid and phenylmethylamine (Benzylamine) that has been shown to act as a hypermnesic drug in humans; it was first synthesized by medical chemistry professor Nikolaus Hansl at Creighton University in the 1970s as part of his work on amino ethyl meta benzoic acid esters.
Nootropic effects
A single study in humans was reported in 1978. The double-blind trial of PRL-8-53 in 47 healthy volunteers measured its effects on a variety of cognitive measures. 5 mg of the drug was administered orally 2–2.5 hours before the study tasks. Overall improvements in recollection differed based on how many words were recalled under placebo, with the poor performers (six or less words) experiencing a 87.5-105% increase in recollection and the high performers (eight or more words) a 7.9-14% increase which failed to reach statistical significance; when controlling for subjects over the age of 30 only, a 108-152% increase was noted.. No side effects were reported during the trial.
Podcasts:
PRL
ALBUMS
- Kochaj Mnie: Polskie Ballady Rockowe released: 2008
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by Barlow
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by Braille
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Fake I.D.
by: BarlowThe St. Louisa school girl
Corona on her breath
Push up ammunition
Smoke some crystal meth
All she wants to do is rock the big dance floor
Sugar Fairy Princess never been before
Bald headed bouncers counting 1-2-3
She just walked right in and showed her fake I.D. and said…
Sucker, I’m only seventeen
she said…
Sucker, I’m only seventeen
The ruler infiltration
Over enemy lines
On the name of freedom
Win a real good time
4am confession in the bathroom stall
She’s under surveillance and a disco ball
She’s dancing on the speakers, call security
And she just shakes her ass and shows her fake I.D. and says…
Sucker, I’m only seventeen (yeah)
she said…
Sucker, I’m only seventeen
Well she’s a James Bond, side dong? operation Hong Kong
Her daddy’s sleepin now they’ve got the systems gone wrong
Sucker
Well all she wants to do is rock the big dance floor
All she wants to do is rock the big dance floor
All she wants to…
All she wants to…
All she wants to do is rock the big dance floor
Sucker, I’m only seventeen (yeah)
she said…
Sucker, I’m only seventeen
Well she’s a James Bond, side dong? operation Hong Kong
Her daddy’s sleepin now they’ve got the systems gone wrong
All she wants to do is rock the big dance floor
Sucker, I’m only seventeen
Sucker, I’m only seventeen
Sucker, I’m only seventeen
All she wants to do
All she wants to do
All she wants to do is rock the big dance floor
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PRL's 3 IN :30 - March video (City of Roseville, CA)
Public Technologies 04 Mar 2025- 1