PRG can mean:
Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein), also known as PRG2, is a protein which in humans is encoded by the PRG2 gene.
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases.
PRG2 is a 117-residue protein that predominates in eosinophil granules. It is a potent enzyme against helminths and is toxic towards bacteria and mammalian cells in vitro. The eosinophil major basic protein also causes the release of histamine from mast cells and basophils, and activates neutrophils and alveolar macrophages.
Proteoglycan 4 or lubricin is a proteoglycan that in humans is encoded by the PRG4 gene. This proteoglycan acts as a joint/boundary lubricant.
Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Lubricin, MSF, and SZP are now collectively known as Proteoglycan 4 (hence PRG4 for the gene nomenclature). The expression of lubricin has also been detected and the protein localized in tendon,meniscus,lung, liver, heart, bone,ligament, muscle, and skin.
The protein encoded by this gene is a proteoglycan of approximately 345 kDa specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. The cDNA encodes a protein of 1,404 amino acids (human A isoform) with a somatomedin B homology domain, heparin-binding domains, multiple mucin-like repeats, a hemopexin domain, and an aggregation domain. There are 3 consensus sequences for N-glycosylation and 1 chondroitin sulfate substitution site.
More nightmares
Someone wake me when they're through
Stop my lover's ghost from trying to protrude
(You're burning, you're burning)
It's chaotic, but I've got it
You're letter scratched across my throat
Like some painter's ink, spilled the canvas soiling parts of me
Cover up, cover up, all the fusion's lost
I know this sucks but one day you'll meet up
I miss the softness of your sound
The taste of you left in my mouth
Is Mississippi done yet burning?
Sick sounds like stomach's stinging
I search out, but you cannot be found
A red horizon in the south
Is Mississippi done yet burning?
Most nights bleat every feeling
I must get back to you somehow
I must get back to you
Your shadow
Now lies against the moon
The skin I touched that once
Kissed has come unglued
(You're burning, you're burning)
It's chaotic, but I've got it
More screams than anyone should hear
The voice of you stabs in my chest
Forged and faithless
Cover up, cover up, all the fusion's lost
I know this sucks but one day you'll meet up
I miss the softness of your sound
The taste of you left in my mouth
Is Mississippi done yet burning?
Sick sounds like stomach's stinging
I search out, but you cannot be found
A red horizon in the south
Is Mississippi done yet burning?
Most nights bleat every feeling
I must get back to you somehow
I must get back to you
Darling boy
Lift your chin up for me now
For my face to see
And I am smiling looking down
I know you're out of breath
You're hit by the way I've left
Just hold me tried and true
For I'll be waiting
Waiting here for you
So dim these lights, I won't be found
This haunting stops right here and now
There's pain and in his eyes of fixed dreaming
I'm tired without you, so let it be
So dim these lights, I won't be found
This haunting stops right here and now
There's pain in his eyes of fixed dreaming
I'm tired without you, so let it be
Is Mississippi done yet burning?
Most nights bleat every feeling
I must get back to you somehow