PRB (company)
PRB is an Australian builder of Clubman-style sportscars (i.e. cars based on Colin Chapman's ground-breaking Lotus Super Seven design), the PRB Clubman was created by Peter Raymond Bladwell in 1978. Bladwell's first order was received from John Ribeiro, a racing driver from Canberra, Australian Capital Territory, who went on to win the New South Wales State Hill Climb Championship in his PRB. There are now several hundred PRB Clubmans on Australian roads. The cars compete very successfully, primarily in Club motorsport. An acceleration time of 0 – 100 km/h in less than 4 seconds is achievable in a modified car.
The current PRB clubman is a composite monocoque design utilising aluminium honeycomb construction. It is only available as a build it yourself kit for owner assembly, or can be assembled by a local PRB agent. The aluminium construction makes for a lighter and more rigid car.
The PRB S3 differentiates itself from many of the other kit cars available in Australia by using mostly new parts, many fabricated specifically for the S3. The latest model S3 utilises an engine from a Ford Focus, Toyota Celica or for racing purposes a Toyota 4AGE 1600.
Company
A company is an association or collection of individuals, whether natural persons, legal persons, or a mixture of both. Company members share a common purpose and unite in order to focus their various talents and organize their collectively available skills or resources to achieve specific, declared goals. Companies take various forms such as:
A company or association of persons can be created at law as legal person so that the company in itself can accept Limited liability for civil responsibility and taxation incurred as members perform (or fail) to discharge their duty within the publicly declared "birth certificate" or published policy.
Because companies are legal persons, they also may associate and register themselves as companies – often known as a corporate group. When the company closes it may need a "death certificate" to avoid further legal obligations.
Company (Heroes)
The Company refers to a fictional covert international organization in the NBC drama Heroes. Its primary purpose is to identify, monitor and study those individuals with genetically-derived special abilities. The Company played a central role in the plot of Volume Two, during the second season of the series. It is a very notable organization in the series and is connected to several of the characters.
Founders
In season two, Kaito Nakamura revealed that there were twelve founders of the Company, and a photo of the twelve is later seen (listed below under "Group photo"); it did not include Adam Monroe, an immortal human with the ability of rapid cellular regeneration, who is described as the one who "brought them all together." The Company began sometime between January 1977 and February 14, 1977. Monroe was locked away for thirty years on November 2, 1977, concluding that he only spent about 10 to 11 months with the Company. In the first season of the show, Daniel Linderman heads the Company until his demise. He is substituted in the second season by Bob Bishop, who is implied to be the Company's financial source. However, when Sylar kills him in the beginning of Season 3, Angela Petrelli takes over. Several of the founders have children who are posthumans and who are main characters within the series.
Company (disambiguation)
A company is a group of more than one persons to carry out an enterprise and so a form of business organization.
Company may also refer to:
In titles and proper names:
PRB
PRB may refer to:
PRB is short for:
Retinoblastoma protein
The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, pRb is phosphorylated, becomes inactive and allows cell cycle progression. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases.
Rb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins. Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomaviruses, bind and inactivate pRb, this can lead to cancer.
Name and genetics
In humans, the protein is encoded by the RB1 gene located on 13q14.1-q14.2. If both alleles of this gene are mutated early in life, the protein is inactivated and results in development of retinoblastoma cancer, hence the name Rb. Retinal cells are not sloughed off or replaced, and are subjected to high levels of mutagenic UV radiation, and thus most pRB knock-outs occur in retinal tissue (but it's also been documented in certain skin cancers in patients from New Zealand where the amount of UV radiation is significantly higher).
