PRB

PRB may refer to:

  • Paso Robles Municipal Airport, IATA designation
  • PRB (car), Australian Automotive Manufacturer
  • PRB (vessel)
  • The unofficial ISO 4217 code for the Transnistrian ruble
  • PRB is short for:

  • Powder River Basin, geologic basin in USA with large coal deposits
  • Brazilian Republican Party, (Partido Republicano Brasileiro, in Portuguese)
  • Pre-Raphaelite Brotherhood of artists
  • Population Reference Bureau
  • Parti Rakyat Brunei, former political party in Brunei
  • Phosphorylated Retinoblastoma protein, pRb
  • People's Republic of Bulgaria
  • Physical Review B, physics journal
  • Permeable Reactive Barrier, for groundwater remediation
  • Poudreries Réunies de Belgique SA, former Belgium armaments manufacturer
  • Periodic Review Board,
  • Retinoblastoma protein

    The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, pRb is phosphorylated, becomes inactive and allows cell cycle progression. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases.

    Rb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins. Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomaviruses, bind and inactivate pRb, this can lead to cancer.

    Name and genetics

    In humans, the protein is encoded by the RB1 gene located on 13q14.1-q14.2. If both alleles of this gene are mutated early in life, the protein is inactivated and results in development of retinoblastoma cancer, hence the name Rb. Retinal cells are not sloughed off or replaced, and are subjected to high levels of mutagenic UV radiation, and thus most pRB knock-outs occur in retinal tissue (but it's also been documented in certain skin cancers in patients from New Zealand where the amount of UV radiation is significantly higher).

    PRB (company)

    PRB is an Australian builder of Clubman-style sportscars (i.e. cars based on Colin Chapman's ground-breaking Lotus Super Seven design), the PRB Clubman was created by Peter Raymond Bladwell in 1978. Bladwell's first order was received from John Ribeiro, a racing driver from Canberra, Australian Capital Territory, who went on to win the New South Wales State Hill Climb Championship in his PRB. There are now several hundred PRB Clubmans on Australian roads. The cars compete very successfully, primarily in Club motorsport. An acceleration time of 0 – 100 km/h in less than 4 seconds is achievable in a modified car.

    The current PRB clubman is a composite monocoque design utilising aluminium honeycomb construction. It is only available as a build it yourself kit for owner assembly, or can be assembled by a local PRB agent. The aluminium construction makes for a lighter and more rigid car.

    The PRB S3 differentiates itself from many of the other kit cars available in Australia by using mostly new parts, many fabricated specifically for the S3. The latest model S3 utilises an engine from a Ford Focus, Toyota Celica or for racing purposes a Toyota 4AGE 1600.

    Podcasts:

    PLAYLIST TIME:

    Laughing

    by: Pere Ubu

    My baby says, my baby says
    We can live in the empty spaces of this life
    My baby says, my baby says
    Far away the stars are coming all undone
    My baby says, my baby says
    My baby says, but that's far away
    and we're young
    My baby says, my baby says
    And if the devil comes we'll shoot him with a gun
    My baby says, my baby says
    We can live in the empty spaces of this life
    My baby says, my baby says
    In the desert sands our hearts are brighter than the sun
    My baby says, my baby says
    When the devil comes we'll shoot him with a gun
    My baby says, my baby says




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