Peroxisome proliferator-activated receptor gamma (PPAR-γ or PPARG), also known as the glitazone receptor, or NR1C3 (nuclear receptor subfamily 1, group C, member 3) is a type II nuclear receptor that in humans is encoded by the PPARG gene.
PPARG is mainly present in adipose tissue, colon and macrophages. Two isoforms of PPARG are detected in the human and in the mouse: PPAR-γ1 (found in nearly all tissues except muscle) and PPAR-γ2 (mostly found in adipose tissue and the intestine).
PPARG regulates fatty acid storage and glucose metabolism. The genes activated by PPARG stimulate lipid uptake and adipogenesis by fat cells. PPARG knockout mice fail to generate adipose tissue when fed a high-fat diet.
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Alternatively spliced transcript variants that encode different isoforms have been described.
More nightmares
Someone wake me when they're through
Stop my lover's ghost from trying to protrude
(You're burning, you're burning)
It's chaotic, but I've got it
You're letter scratched across my throat
Like some painter's ink, spilled the canvas soiling parts of me
Cover up, cover up, all the fusion's lost
I know this sucks but one day you'll meet up
I miss the softness of your sound
The taste of you left in my mouth
Is Mississippi done yet burning?
Sick sounds like stomach's stinging
I search out, but you cannot be found
A red horizon in the south
Is Mississippi done yet burning?
Most nights bleat every feeling
I must get back to you somehow
I must get back to you
Your shadow
Now lies against the moon
The skin I touched that once
Kissed has come unglued
(You're burning, you're burning)
It's chaotic, but I've got it
More screams than anyone should hear
The voice of you stabs in my chest
Forged and faithless
Cover up, cover up, all the fusion's lost
I know this sucks but one day you'll meet up
I miss the softness of your sound
The taste of you left in my mouth
Is Mississippi done yet burning?
Sick sounds like stomach's stinging
I search out, but you cannot be found
A red horizon in the south
Is Mississippi done yet burning?
Most nights bleat every feeling
I must get back to you somehow
I must get back to you
Darling boy
Lift your chin up for me now
For my face to see
And I am smiling looking down
I know you're out of breath
You're hit by the way I've left
Just hold me tried and true
For I'll be waiting
Waiting here for you
So dim these lights, I won't be found
This haunting stops right here and now
There's pain and in his eyes of fixed dreaming
I'm tired without you, so let it be
So dim these lights, I won't be found
This haunting stops right here and now
There's pain in his eyes of fixed dreaming
I'm tired without you, so let it be
Is Mississippi done yet burning?
Most nights bleat every feeling
I must get back to you somehow