DNA polymerase alpha catalytic subunit is an enzyme that in humans is encoded by the POLA1 gene.
Pol α has limited processivity and lacks 3′ exonuclease activity for proofreading errors. Thus it is not well suited to efficiently and accurately copy long templates (unlike Pol Delta and Epsilon). Instead it plays a more limited role in replication. Pol α is responsible for the initiation of DNA replication at origins of replication (on both the leading and lagging strands) and during synthesis of Okazaki fragments on the lagging strand. The Pol α complex (pol α-DNA primase complex) consists of four subunits: the catalytic subunit POLA1, the regulatory subunit POLA2, and the small and the large primase subunits PRIM1 and PRIM2 respectively. Once primase has created the RNA primer, Pol α starts replication elongating the primer with ~20 nucleotides.
DNA dependent polymerase alpha (Pol α) has been shown to interact with Retinoblastoma protein,PARP1 and RBMS1.
DNA polymerase alpha also known as Pol α is an enzyme complex found in eukaryotes that is involved in initiation of DNA replication. The DNA polymerase alpha complex consists of 4 subunits: POLA1, POLA2, PRIM1, and PRIM2.
Pol α has limited processivity and lacks 3′ exonuclease activity for proofreading errors. Thus it is not well suited to efficiently and accurately copy long templates (unlike Pol Delta and Epsilon). Instead it plays a more limited role in replication. Pol α is responsible for the initiation of DNA replication at origins of replication (on both the leading and lagging strands) and during synthesis of Okazaki fragments on the lagging strand. The Pol α complex (pol α-DNA primase complex) consists of four subunits: the catalytic subunit POLA1, the regulatory subunit POLA2, and the small and the large primase subunits PRIM1 and PRIM2 respectively. Once primase has created the RNA primer, Pol α starts replication elongating the primer with ~20 nucleotides.
Don't you cry, don't you look so sad
We both knew somehow this day would come
I know you want what is best for me
And I need to see you smile
From where I started off to where I am
It's a million miles, I can't go back there again
But no matter where I go from here
You will be part of me from now on
For every door that opens up
When another has to close
You got to trust me now
Be strong and let me go
Watch me now as I go my way
The time has come
And I gotta say I'm not afraid
Watch me now, every step I take
I feel stronger, so much stronger
The road ahead is a mystery
Your love is here
Oh and I believe inside of me
Watch me now, I can stand my ground
I will be alright, yes I'll be alright
You were someone who believed in me
When I wasn't even sure of myself
And I always will remember how
You were always there to help
And I heard so many things from you
And I'm ready now to try them out in the world
Though it hurts too much to say goodbye
We both know (We both know)
There's no other way
I will feel your loving arms
When I'm out there in the cold
'Cause all of my thoughts of you
Will still be mine to hold
Watch me now as I go my way
The time has come
And I gotta say I'm not afraid
Watch me now, every step I take
I feel stronger, so much stronger
The road ahead is a mystery
Your love is here
Oh and I believe inside of me
Watch me now, I can stand my ground
I will be alright, yes I'll be alright
You will find me running back sometime
When I really need a guiding hand
We'll be closer than we were before
And I know that you will understand
I know you'll understand
Watch me now as I go my way
The time has come
And I gotta say I'm not afraid
Watch me now, every step I take
I feel stronger, so much stronger
The road ahead is a mystery
Your love is here
Oh and I believe inside of me
Watch me now, I can stand my ground
I will be alright, yes I'll be alright