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Digital model railway control systems
A number of control systems are available to operate locomotives on model railways. The earlier traditional analog systems where the speed and the direction of a train is controlled by adjusting the voltage on the track are still popular while they have recently given way to control systems based on computer technology. Digital model railway control systems are the modern alternative to control a layout and greatly simplify the wiring and add more flexibility in operations.
Digital model railway control system basics
Some digital control systems provide the ability to independently control all aspects of operating a model railway using a minimum of wiring, the rails themselves can be the only wiring required.Other systems are truly wireless. Control is achieved by sending a digital signal as well as power down the rails or wirelessly. These digital signals can control all aspects of the model trains and accessories, including signals, turnouts, lighting, level crossings, cranes, turntables, etc.
Peripheral myelin protein 22
Growth arrest-specific protein 3 (GAS-3), also called peripheral myelin protein 22 (PMP22), is a protein which in humans is encoded by the PMP22 gene.
PMP22 is a 22 kDa transmembrane glycoprotein made up of 160 amino acids, and is mainly expressed in the Schwann cells of the peripheral nervous system. Schwann cells show high expression of PMP22, where it can constitute 2-5% of total protein content in compact myelin. Compact myelin is the bulk of the peripheral neuron's myelin sheath, a protective fatty layer that provides electrical insulation for the neuronal axon. The level of PMP22 expression is relatively low in the central nervous system of adults.
Like other membrane proteins, newly translated PMP22 protein is temporarily sequestered to the endoplasmic reticulum (ER) and Golgi apparatus for post-translational modifications. PMP22 protein is glycosylated with an N terminus-linked sugar and co-localized with the BiP chaperone protein in the ER. After the protein is transported to the Golgi apparatus it can then become incorporated in the plasma membrane of the cell.
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