PKC alpha

Protein kinase C alpha (PKCα) is an enzyme that in humans is encoded by the PRKCA gene.

Function

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca²⁺ handling in myocytes.

Protein kinase C-alpha (PKC-α) is a specific member of the protein kinase family. These enzymes are characterized by their ability to add a phosphate group to other proteins, thus changing their function. PKC-α has been widely studied in the tissues of many organisms including drosophila, xenopus, cow, dog, chicken, human, monkey, mouse, pig, and rabbit. Many studies are currently being conducted investigating the structure, function, and regulation of this enzyme. The most recent investigations concerning this enzyme include its general regulation, hepatic function, and cardiac function.

Absolute Return + Alpha

AR: Absolute Return + Alpha (or AR) is a hedge fund magazine founded in 2009. The magazine has its editorial offices in New York City.

History and profile

Absolute Return + Alpha (AR) was launched in September 2009, as a subsidiary of financial publisher Euromoney Institutional Investor.AR was formed when two magazines, Alpha and Absolute Return, were combined. The magazine publishes both online and print content. Its main focus is the hedge fund industry and its 3,500 fund managers, but the magazine also covers significant financial events and global research. The magazine features hedge fund rankings according to assets under management rankings, an annual ranking of the 25 highest paid hedge fund managers, and monthly tables of U.S. hedge fund performance data.

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Selena albums discography

American singer Selena has released five studio albums, three live albums, one soundtrack and twenty-one compilation albums. Credited for elevating a music genre into the mainstream market, Selena remains the best-selling Tejano recording artist whose posthumous releases continue to outsell those of living musicians. As of 2015, the singer has sold 60 million copies worldwide, and was named the "Top Latin Artist of the '90s" and "Best-selling Latin Artist of the Decade" by Billboard magazine. In 1995, Selena was inducted into the Billboard Latin Music Hall of Fame, the Hard Rock Cafe's Hall of Fame, the South Texas Music Hall of Fame, and the Tejano Music Hall of Fame in 2001.

Selena's career began as lead vocalist of Los Dinos in 1980. She signed with EMI Latin nine years later as a solo artist though her band continued to tour with her. She released her self-titled debut album that same year, which peaked at number seven on the U.S. Billboard Regional Mexican Albums chart. With Selena, the singer outsold other female Tejano artists. She released her second album Ven Conmigo in October 1990; it peaked at number three on the Regional Mexican Albums chart. Ven Conmigo was later certified gold by the Recording Industry Association of America (RIAA) for shipments of 50,000 units, the first recording by a female Tejano artist to do so. As of 2010, Ven Conmigo had sold 500,000 copies in the United States. According to music critics, her next recording Entre a Mi Mundo (1992), was the "breakthrough album" of her musical career. The album and its lead single, "Como la Flor", helped launch the singer's career in Mexico.Entre a Mi Mundo peaked at number one on the Regional Mexican Albums chart for eight consecutive months; and was certified 6× platinum by the RIAA, signifying shipments of 600,000 units. Entre a Mi Mundo became the first Tejano recording by a female artist to sell over 300,000 copies.

Limited Edition (Magic: The Gathering)

Magic: The Gathering Limited Edition is the first Magic: The Gathering card set. It premiered in a limited release at Origins Game Fair in 1993, with a general release that August. The initial print run of 2.6 million cards sold out quickly, and a new printing run was released in October 1993. These two runs are known as Limited Edition Alpha and Limited Edition Beta, or just Alpha and Beta for short. Although Alpha and Beta are referred to as different sets by some, officially they are the same set; Wizards of the Coast had expected that people wouldn't necessarily be able to tell the two press runs apart. Beta fixed a number of misprints and errors on cards. The printer accidentally used different corner rounding dies for the second run, resulting in Alpha cards being noticeably distinct in shape and appearance from Beta cards and all subsequent cards. The Beta printing also included a revised rulebook with a number of clarifications, although creator Richard Garfield's short fiction "Worzel's Tale" was removed to make room. The print run of Beta is given as 7.3 million or 7.8 million depending on the source. Despite the set's print run being about three times as big as Alpha's, Beta sold out as quickly as its predecessor.