POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1), also known as POU1F1, is a transcription factor for growth hormone.
PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 (MIM 164175) of mammals, and Unc-86 of C. elegans (Herr et al., 1988). PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone (GH; MIM 139250) and prolactin (PRL; MIM 176760). PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit (TSHB; MIM 188540) by thyrotropin-releasing hormone (TRH; MIM 257120) and cyclic AMP.[supplied by OMIM]
I'll open up if you make an incision
I'll do right by you
All I ask is for your care and precision
And maybe I could pull through
You could've saved me if you'd only known better
But you so carlessly
Took me apart and put me back together
Open heart surgery
I was fine at first
Now I assume the worst
When I could overhear
The repercussions of a sad discussion
Another girl in tears
I could've saved here if I only knew better
That you so carelessly
Took her apart and put her back together
Open heart surgery
If girls like you and girls like me
Are really a dime a dozen
Why are we in such a high demand
My mother says it's just a shame you don't come around too often
Even she's begun to understand
Just let me know
What you were thinking
I find a way to get along somehow
Just let me go
Don't leave me hanging
Oh, please don't fail me now
Just take it slow
Don't let me suffer
I'm on the verge of an emergency
The final blow
Will make me tougher
Until then you will always be
A danger to me
We should've listened to our intuition
But we knew all to well
In addition to our suspicions
Only time could tell
With friends like you I get confused
Who needs enemies
We've been here too many times before
Open heart surgery
If girls like you and girls like me
Are really a dime a dozens
Why are we in such a high demand
My mother says it's just a shame you don't come around too often
Even she's begun to understand
Just let me know
What you were thinking
I find a way to get along somehow
Just let me go
Don't leave me hanging
Oh, please don't fail me now
Just take it slow
Don't let me suffer
I'm on the verge of an emergency
The final blow
Will make me tougher
Until then you will always be
A danger to me
A danger to me
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