P110α
The phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (the HUGO-approved official symbol = PIK3CA; HGNC ID, HGNC:8975), also called p110α protein, is a class I PI 3-kinase catalytic subunit. The human p110α protein is encoded by the PIK3CA gene.
Function
Phosphatidylinositol-4,5-bisphosphate 3-kinase (also called phosphatidylinositol 3-kinase) is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate phosphatidylinositols (PtdIns), PtdIns4P and PtdIns(4,5)P2.
Clinical significance
Recent evidence has shown that the PIK3CA gene is mutated in a range of human cancers. It has been found to be oncogenic and has been implicated in cervical cancers.
Due to the association between p110α and cancer, it is believed to be a promising drug target. A number of pharmaceutical companies are currently designing and charactering potential p110α isoform specific inhibitors. The presence of PIK3CA mutation may predict response to aspirin therapy for colorectal cancer, indicating power and promise of "Molecular Pathological Epidemiology (MPE)" approach as well as a complex interaction within the tumor microenvironment in this phenomenon.
Podcasts:
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by Big Wig
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by Buck 65
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Sellout
by: Big WigHit the block around twenty to nine,
Checking my girl
But then I see this girl lookin' fine, so I
Asked her if she wouldn't mind,
Could you tell me your name and what you're doing tonight ?
Body like nothin' I seen,
She's telling me she's on the cover of GQ magazine.
Tellin' me she had to go...
So I dropped her at the spot in my four by four
- Bridge
So I told her ...
I can't be late,
The girl's taking up my time,
Had to hit her with a line,
So I told her ...
I can't wait to freak,
See you at the same time next week.
She said ...
- Chorus
Baby give me what you got,
Cos I'm everything that's she's not.
Love is all I bring,
In my khaki suit and thing.
So honey leave your girl at home,
With your car keys, mobile phone.
Love is all I got,
All the things that make you hot
Got my woman crazy on the phone,
She's talking bout why the f*** my ass ain't at home.
Had to tell her I was stuck,
In some brand new business, I was all tied up.
Told the girl I was late,
I had to rhyme.
I got to be backstage at a quarter past nine.
Telling me to change my mind ...
She's like Britney Spears Baby hit me one more time ...
- Bridge
- Chorus