PIK3C2A
Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide is an enzyme that in humans is encoded by the PIK3C2A gene.
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmannin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.
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Further reading
Podcasts:
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by Big Cock
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by Big Cock
Don't Ask Me To Be Faithful
by: Big CockNever said that I was perfect
All the crazy things I do
All the loving we made
I wouldn't trade, girl I love you
But falling in love was not the plan
So honey try to understand
The only thing I can do
Is promise to you, that I won't be true
Don't ask me to be Faithful
‘Cos I've tried so many times
I don't think that I am able
All I am is what I lay out on the table
Don't ask me, don't ask me to be Faithful
You know I hate to lie
I don't have a reason why
To hurt you deliberately
Why can't you see, the others
They don't mean a thing to me
Don't ask me to be Faithful
‘Cos I've tried so many times
I don't think that I am able
All I am is what I lay out on the table
Don't ask me, don't ask me to be Faithful
You want the man I'll never be
I'll be yours unfaithfully
I know in time that when you cry you'll realise
My love is not a crime
Don't ask me to be Faithful
‘Cos I've tried so many times
I don't think that I am able
All I am is what I lay out on the table
Don't ask me, don't ask me