PHC

PHC may refer to:

In cities

In education

In health care

In religion

In science

Transport

PHC3

Polyhomeotic-like protein 3 is a protein that in humans is encoded by the PHC3 gene.

References

Further reading

PHC1

Polyhomeotic-like protein 1 is a protein that in humans is encoded by the PHC1 gene.

Function

This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein.

Mutations in this gene have been associated to cases of primary microcephaly (doi: 10.1093/hmg/ddt072).

Interactions

PHC1 has been shown to interact with BMI1 and PHC2.

References

Further reading