Prostaglandin D2
Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR (DP1), as well as CRTH2 (DP2). It is a major prostaglandin produced by mast cells – recruits Th2 cells, eosinophils, and basophils. In mammalian organs, large amounts of PGD2 are found only in the brain and in mast cells. It is critical to development of allergic diseases such as asthma.
Research carried out in 1989 found PGD2 is the primary mediator of vasodilation (the "niacin flush") after ingestion of niacin (nicotinic acid).
A 2012 research paper indicates a causal link between elevated levels of localized PGD2 and hair growth inhibition. Applied topically, the researchers found PGD2 prevents hair growth, and mice that were genetically inclined to produce higher levels of PGD2 had inhibited hair growth. The researchers also found PGD2 levels were much higher in balding scalp tissue than nonbalding scalp tissue, through increased levels of prostaglandin D2 synthase. The paper suggested that inhibition of hair growth involved binding of PGD2 to a receptor called GPR44, and that GPR44 therefore would be a therapeutic target for androgenic alopecia in both men and women with hair loss and thinning. Because PGD2's relation to asthma has been known for several years, several drugs that seek to reduce the effect of PGD2 through blocking the GPR44 are already in clinical trials.
Podcasts:
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by Jaheim
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by Toad The Wet Sprocket
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by T.A.T.U.
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by Mischief Brew
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by Caterina Valente
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by Tommy Torres
Backtight
by: JaheimLookin back on all i put you thru
to much of a thug nigga to tell you that i love you (i love you)
i know that i made mistakes been hopein and prayin that it aint to late
thought i had my game tight thought i had it lockdown knew when shit wasnt right
now you want to blow before i let you go theres something you just gotta know
(chorus)
aint nothing stopin me from gettin backtight wit you
go head and dip you got tha right to if i gotta roll up my sleeves
and fight for you ill stand outside in rain all night for you
aint nothing stopin me from gettin backtight wit you
go head and dip you got tha right to if i gotta roll up my sleeves
and fight for you ill stand outside in the rain all night
three months three weeks two days its tha same shit shorty she aint havein it
back then i wasnt serious makein so much paper kept em curious
chickens cluckin everywhere i didnt care thinkin to myself that you'll always be there
used to makein love to ya lady i wouldnt rather be pushin my mercades
(chorus)
aint nothing stopin me from gettin backtight wit you
go head and dip you got tha right to if i gotta roll up my sleeves
and fight for you ill stand outside in rain all night for you
aint nothing stopin me from gettin backtight wit you
go head and dip you got tha right to if i gotta roll up my sleeves
and fight for you ill stand outside in the rain all night
(repeat chorus)
if tha sun was to fall and tha stars was to lose they shine
i'd be content with it all as long as your bay myside girl
thru tha good thru tha bad thru it all girl i need ya back
ill always be with you just want to please you