PDE11A
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene.
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
Inhibitors
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Further reading
Podcasts:
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Boom
by: P.O.D.Push up
Haha, I never knew that a kid like me
Could take his mic around the world
(World)
Flash the big S.D.
And rock the masses
From Madrid to Calabasas
Tijuana, Mexico
Bootleg demos in Tokyo
Say they know me though
'Cause I'll be puttin' in work
Commit my life to rebirth
Well respected, 'cause that's my word
And I'm sure you heard
(Heard)
'Bout a new sound goin' 'round
She might have left my hood
But she was born in my town
You didn't know, thought we was new on the scene
(Well it's alright, it's alright)
I know you know, I see you smilin' at me
(Well it's alright, it's alright)
Boom!
Here comes the
Boom!
Ready or not?
Here comes the boys from the South
Boom!
Here comes the
Boom!
Ready or not?
How you like me now?, I say
We rep the South
So what you talkin' 'bout?
I'm not runnin' off my mouth
I know this without a doubt
'Cause if you know these streets
Then these streets know you
An' when it's time to handle business
Then you know what to do
(What to do)
Me and my crew
We stay true, old skool or new
Many were called
But the chosen are few
(We are few)
We rise to the top
What you want, just in case you forgot
Rush the stage, grab my mic
Show me what you got?
You didn't know, thought we was new on the scene
(Well it's alright, it's alright)
I know you know, I see you smiling at me
(Well it's alright, it's alright)
Boom!
Here comes the
Boom!
Ready or not?
Here comes the boys from the South
Boom!
Here comes the
Boom!
Ready or not ?
How you like me now?, I say
Boom!
Here comes the
Boom!
Ready or not?
Here comes the boys from the South
Boom!
Here comes the
Boom!
Ready or not?
How you like me now?
Is that all you got?, haha
I'll take your best shot
Is that all you got?, ha ha
I'll take your best shot
Is that all you got?, I'll take your best shot
Is that all you got?, I'll take your best shot
Is that all you got?, I'll take your best shot
I'll take your best shot, I'll take your best shot
Is that all you got?
(Well it's alright, it's alright)
I'll take your best shot
Is that all you got?
(Well it's alright, it's alright)
I'll take your best shot
Is that all you got?, I'll take your best shot
(Well it's alright, it's alright)
Take your best shot, take your best shot
Is that all you got?, I'll take your best shot
(Well it's alright, it's alright)
Take your best shot, take your best shot
Boom!
Here comes the
Boom!
Ready or not?
Here comes the boys from the South
Boom!
Here comes the
Boom!
Ready or not?
Haha, how you like me now?, I say
Boom!
Here comes the
Boom!
Ready or not?
Here comes the boys from the South
Boom!
Here comes the
Boom!
Ready or not?