Proliferating cell nuclear antigen
Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin remodeling and epigenetics.
Many proteins interact with PCNA via the two known PCNA-interacting motifs PCNA-interacting peptide (PIP) box and AlkB homologue 2 PCNA interacting motif (APIM). Proteins binding to PCNA via the PIP-box are mainly involved in DNA replication whereas proteins binding to PCNA via APIM are mainly important in the context of genotoxic stress.
Function
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.
Podcasts:
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by Boa Kwon
I See Me
by: Boa KwonItsumo yori sukoshi toomawari shite aruita kaerimichi
Natsukashii fuyu no nioi ni futoashi ga tomaru
Osanai koro kokoro ni ukabe teta yume
Kanaeta kazu dake yubiori kaunto shite mo
Shiroi tame iki...
Kigatsukeba hoshin to jounetsu no hazama
Utsurou kisetsu ni yudaneru hodo
Kasumu ano koro omoiegaita mirai
"Demo, korede ii" tte kokoro ga iu
Miraizu wo nazoru kawari ni
Te ni shita ima wo daite
Susunde de yuku dake I SEE ME
Nakushita mono, tsukanda mono
Kakenuketa hibi wo
Asu e tsumuide yuku
Kono nigami ga watashi no michishirube
Shingou machi de futo omoikaeshita kotoba wa
Watashirashi-sa o mamoru katedatta no ka naa
Kasena no ka naa
Kotae nado imi no nai kotoba asobi
Demo toikakete sagashite ashiato nokosu
Hie kitta te nigirishimete
"Demo, korede ii" tte kokoro ga iu
Miraizu wo nazoru kawari ni
Te ni shita ima wo daite
Susunde de yuku dake I SEE ME
Nakushita mono, tsukanda mono
Kakenuketa hibi wo
Asu e tsumuide yuku
Kono nigami ga watashi no michishirube
Furui yume ni se wo mukete hitomi tojirunara
Watashi, hontou ni kanaetakatta no?
Natsukashii itami ga kono mune no naka de uzuita toshite mo
Obutsukanai hibi no +wake ni wa dekinai
(I will never can let go, let it go, let it go)
Keep on keepin' on I'll keep it on
Tooi fuukei ni
I SEE ME... I SEE ME
"Demo, korede ii" tte kokoro ga iu
Miraizu wo nazoru kawari ni
Te ni shita ima wo daite
Susunde de yuku dake I SEE ME
Nakushita mono, tsukanda mono
Kakenuketa hibi wo
Asu e tsumuide yuku