PBX2

Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.

Interactions

PBX2 has been shown to interact with HOXA9.

References

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Polymer-bonded explosive

A polymer-bonded explosive, also called PBX or plastic-bonded explosive, is an explosive material in which explosive powder is bound together in a matrix using small quantities (typically 5–10% by weight) of a synthetic polymer ("plastic"). Note that despite the word "plastic", polymer-bonded explosives are not hand malleable after curing, and hence are not a form of plastic explosive. PBXs are normally used for explosive materials that are not easily melted into a casting, or are otherwise difficult to form. PBX was first developed in 1952 in Los Alamos National Laboratory, as RDX embedded in polystyrene with dioctyl phthalate plasticizer. HMX compositions with teflon-based binders were developed in 1960s and 1970s for gun shells and for Apollo Lunar Surface Experiments Package (ALSEP) seismic experiments, although the latter experiments are usually cited as using Hexanitrostilbene (HNS).

Potential advantages

Polymer-bonded explosives have several potential advantages: