Pathogen-associated molecular pattern
Pathogen-associated molecular patterns, or PAMPs, are molecules associated with groups of pathogens, that are recognized by cells of the innate immune system. These molecules can be referred to as small molecular motifs conserved within a class of microbes. They are recognized by Toll-like receptors (TLRs) and other pattern recognition receptors (PRRs) in both plants and animals. A vast array of different types of molecules can serve as PAMPs, including glycans and glycoconjugates.
PAMPs activate innate immune responses, protecting the host from infection, by identifying some conserved nonself molecules. Bacterial lipopolysaccharides (LPSs), endotoxins found on the cell membranes of bacteria, are considered to be the prototypical class of PAMPs. LPSs are specifically recognised by TLR4, a recognition receptor of the innate immune system. Other PAMPs include bacterial flagellin (recognized by TLR5), lipoteichoic acid from gram-positive bacteria, peptidoglycan, and nucleic acid variants normally associated with viruses, such as double-stranded RNA (dsRNA), recognized by TLR3 or unmethylated CpG motifs, recognized by TLR9. Although the term "PAMP" is relatively new, the concept that molecules derived from microbes must be detected by receptors from multicellular organisms has been held for many decades, and references to an "endotoxin receptor" are found in much of the older literature.
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Bombs
by: FaithlessSo much more than I thought this world could ever hold
So much more than I thought this world could ever hold
We think we're heroes, we think we're kings
We plan all kinds of fabulous things
Oh, look how great we have become
Key in the door, the moment I've been longing for
Before my bag hit the floor
My adorable children rush up screaming for a kiss
And a story they're a gift to this world
My only claim to glory, I surely never knew sweeter days
Blows my mind like munitions, I'm amazed
So much heaven, so much hell, so much love, so much pain
So much more than I thought this world could ever contain
So much war, so much soul, one man's loss, another man's gold
So much more than I thought this world could ever hold
We're just children, we're just dust, we are small and we are lost
And we're nothing, nothing at all
One bomb, the whole block gone
Can't find me children and dust covers the sun
Everywhere is noise, panic and confusion
But to some another fun day in Babylon
I'm gonna bury my wife and dig up my gun
My life is done, so now I've got to kill someone
So much heaven, so much hell, so much love, so much pain
So much more than I thought this world could ever contain
So much war, so much soul, moments lost, moments go
So much more than I thought this world could ever hold
So much more than I thought this world could ever hold
So much more than I thought this world could ever hold
So much heaven, so much hell, so much love, so much pain
So much more than I thought this world could ever contain
So much war, so much soul, moments lost, moments go