PALB2
Partner and localizer of BRCA2, also known as PALB2 or FANCN, is a protein which in humans is encoded by the PALB2 gene.
Function
This gene encodes a protein that functions in genome maintenance (double strand break repair). This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. PALB2 binds the single strand DNA and directly interacts with the recombinase RAD51 to stimulates strand invasion a vital step of homologous recombination. PALB2 can function synergistically with a BRCA2 chimera (termed piccolo, or piBRCA2) to further promote strand invasion.
Clinical significance
Variants in the PALB2 gene are associated with an increased risk of developing breast cancer of magnitude similar to that associated with BRCA2 mutations and PALB2-deficient cells are sensitive to PARP inhibitors.
PALB2 was recently identified as a susceptibility gene for familial pancreatic cancer by scientists at the Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins. This has paved for the way for developing a new gene test for families where pancreatic cancer occurs in multiple family members. Tests for PALB2 have been developed by Ambry Genetics and Myriad Genetics that are now available. The PALB2 Interest Group (PALB2.org) is an international consortium of scientists and clinicians who coordinate research into this gene.
Podcasts:
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by Bob
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by Heinz Rudolf Kunze
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by Nits
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by Chingy
Blow
by: BobBLOWWWW BLOOOWWWW
[B.o.B - Rap Verse]
Just while then
Shades on my face
Eyes on my kicks
Lights on my face
Speakers gon' blow
Speakers got bass
Bottles on ice
Haters gon' hate
Baller don't care
Baller's so straight
Baller from the hood
So Baller don't play
Baller burn good
What they prolly gon' say
Sicker than the stuff like raviole
So bon appetite
Just got a sipper
Blow like a missile
White clef cush
I've been going to november
Where the grand gripper
Word to manila
You better remember, I'm from the city
Where the shortys and players live
Nice stars out at the ATL
And prolly won't end til 8am
Yeah i'm an ATLien
An extraterrestrial, asses with the vegetable
Up in the air and no parachute
I ain't contested the best in the area
Even the vision of pair, one can tell
Tha you can see Where i'm coming from
And leave all when i'm done
Haters miss me with a bunch joke
Cuz this place's about to blow
I can push stroke here
And ninety feet like a bunch of drunk
Let's go!
WE'RE TAKING OVER....DANCE
[Ke$ha]
Back door cracked
We don't need a key
We get in for free
No VIP sleaze
Drink that Kool-Aid
Follow my lead
Now you're one of us
You're coming with me
It's time to kill the lights
And shut the DJ down
(This place about to)
Tonight were taking over
No one's getting out
This place about to blow
Blow
This place about to blow
Blow
This place about to blow
Blow
This place about to blow
Blow
This place about to
Now what (What)
We're taking control
We get what we want
We do what you don't
Dirt and glitter
Cover the floor
We're pretty and sick
We're young and we're bored (Ha)
It's time to lose your mind
And let the crazy out
(This place about to)
Tonight we're taking names
'Cause we don't mess around
This place about to blow
Blow
This place about to blow
Blow
This place about to blow
Blow
This place about to blow
Blow
This place about to
(Blow)
Go, go, go, go insane
Go insane
Throw some glitter
Make it rain on him
Let me see them Hanes
Let me, let me see them Hanes
Go insane
Go insane
Throw some glitter
Make it rain on him
Let me see them Hanes
Let me, let me see them Hanes (C'mon)
We are taking, over (Blow)
Get used to it, over (Blow)
This place about to blow
Blow
This place about to blow
Blow (Oh)
This place about to blow (Oh)
Blow
This place about to blow
Blow