Serine/threonine-protein kinase PAK 4 is an enzyme that in humans is encoded by the PAK4 gene.
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. PAK4 has been shown to be repressed at translational level by miR-24.
PAK4 has been shown to interact with CDC42,Integrin, beta 5 and LIMK1.
Sometimes I feel so lost S.O.S. all my lines are crossed. I bite off more than I can chew. It's killing me its killing you there's nothing that I'd rather do. It's got me now its holding me. A sign of something good a sign I thought I'd never see. I try to keep it in my head. We'll you can kick my ass and burn your books, but it won't change a word I've said. I guess I should have seen it coming. It's in the smile on his face. Did you really think that this would be so easy? I think you made a big mistake. What went so wrong? Every action has reaction in this fucked up world that you created. Now you're head is so full of negativity and shattered dreams. A world of noise you end up hating. It's got me now it's holding me. A sign of something good a sign I thought I'd never see. I try to keep it in my head. We'll you can kick my ass and burn you're books but it won't change a word I've said. I guess I should have seen it coming. It's in the smile on his face. Did you really think that this would be so easy? I think you made a big mistake. What went so wrong it's been too long. So just take it on the chin. It's who you are and what you do. Not who you were or what you have been. There's just one thing you should know. That I still care to work it out don't think about it let it go.