Serine/threonine-protein kinase PAK 3 is an enzyme that in humans is encoded by the PAK3 gene.
PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity.
A point mutation in this gene has been linked to nonsyndromic X-linked mental retardation.
PAK3 has been shown to interact with RAC1.
Sometimes I feel so lost S.O.S. all my lines are crossed. I bite off more than I can chew. It's killing me its killing you there's nothing that I'd rather do. It's got me now its holding me. A sign of something good a sign I thought I'd never see. I try to keep it in my head. We'll you can kick my ass and burn your books, but it won't change a word I've said. I guess I should have seen it coming. It's in the smile on his face. Did you really think that this would be so easy? I think you made a big mistake. What went so wrong? Every action has reaction in this fucked up world that you created. Now you're head is so full of negativity and shattered dreams. A world of noise you end up hating. It's got me now it's holding me. A sign of something good a sign I thought I'd never see. I try to keep it in my head. We'll you can kick my ass and burn you're books but it won't change a word I've said. I guess I should have seen it coming. It's in the smile on his face. Did you really think that this would be so easy? I think you made a big mistake. What went so wrong it's been too long. So just take it on the chin. It's who you are and what you do. Not who you were or what you have been. There's just one thing you should know. That I still care to work it out don't think about it let it go.