Pituitary adenylate cyclase-activating peptide
Pituitary adenylate cyclase-activating polypeptide also known as PACAP is a protein that in humans is encoded by the ADCYAP1 gene. PACAP is similar to vasoactive intestinal peptide. One of its effects is to stimulate enterochromaffin-like cells. It binds to vasoactive intestinal peptide receptor and to the PACAP receptor.
Function
This gene encodes adenylate cyclase-activating polypeptide 1. Mediated by adenylate cyclase-activating polypeptide 1 receptors, this polypeptide stimulates adenylate cyclase and subsequently increases the cAMP level in target cells. Adenylate cyclase-activating polypeptide 1 not only is a hypophysiotropic hormone (i.e. a substance that induces activity in the hypophysis) but also functions as a neurotransmitter and neuromodulator. In addition, it plays a role in paracrine and autocrine regulation of certain types of cells. This gene is composed of five exons. Exons 1 and 2 encode the 5' UTR and signal peptide, respectively; exon 4 encodes an adenylate cyclase-activating polypeptide 1-related peptide; and exon 5 encodes the mature peptide and 3' UTR. This gene encodes three different mature peptides, including two isotypes: a shorter form and a longer form.
Podcasts:
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by Pegboy
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by Pegboy
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by Pegboy
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by Beau Coup
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by Beau Coup
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by Beau Coup
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by Beau Coup
Still Uneasy
by: PegboyThe other day I said to you
I know what you want to do
I could never sit around
While you´re feeling down
And I could never compromise
My situation lies
And I would never feel the same
Would you be the blame?
Would you leave me
Still uneasy
Locked inside of
Torn in spite of
I don´t want to, I don´t want to know
Sometimes when you´re all alone
Hiding what you´re thinking of
I could never sit around
While you´re feeling down
I could never see my self
Chasing something else
I would never get away
Would you feel the same?
Would you leave me
Still uneasy
Trapped inside of
Torn in spite of
I don´t want to, I don´t want to know
Sometimes when I´m all alone
Feeling what you´re thinking of
And I could never sit around
Chained to frozen ground
I could never see my self
Playing for something else
And I could never walk away
Would you feel the same?
Would you leave me
Still uneasy
Trapped inside of
Torn in spite of