P85
P85 or p85 may refer to:
PIK3R1
Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene.
Function
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in three transcript variants encoding different isoforms.
Clinical significance
Mutations in PIK3R1 are implicated in cases of breast cancer .
Mutations in PIK3R1 are associated to SHORT syndrome .
Interactions
PIK3R1 has been shown to interact with:
PIK3R2
Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.
Interactions
PIK3R2 has been shown to interact with:
Clinical relevance
PIK3R2 mutations were recently shown to be associated with polymicrogyria.
References
Further reading
Podcasts:
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Ball and Chain
by: B4-4I just wanna be your ball and chain
Wrapped around your finger
Locked up, tied me down
Follow you forever
Never let you get away,
Holding on like a ball and chain
I never wanted to stay
In one place too long
Oh no, not me, I didn't wanna be
A victim of that fatal touch
When you want someone too much but
You, you'll be the end of me
And I don't want to hurt anymore
I tried my best to avoid
Making promises
Oh, no, not me, I didn't wanna
be a prisoner of that tender trap
When there's no turning back but
You, you got me on my knees
And I won't be afraid anymore
I just wanna be your ball and chain
Wrapped around your finger
Locked up, tied me down
Follow you forever
Never let you get away,
Holding on like a ball and chain
I know it's been some time confined to be alone
but I know I found the one who's gotts be this love jones
you know that I get open when you rubbing my back the goose bumps
and chills must be proof of that cos I'm feeling when your dealing
all the knowledge you've got about making it good
when your touching my spots I've goy lots of loving
when we bubbling it right I look forward to the time the day turns night
you've gotta meet me at the crib for the quarter to nine
and at the time love devine and what do I find
I won't be afraid anymore
The side of you be wanting me just haunting my fight boy be my ball and chain yo it's gotta be right
I just wanna be your ball and chain
Wrapped around your finger
Locked up, tied me down
Follow you forever
Never let you get away,