P57 may refer to:
Cyclin-dependent kinase inhibitor 1C (p57, Kip2), also known as CDKN1C, is protein which in humans is encoded by the CDKN1C imprinted gene.
Cyclin-dependent kinase inhibitor 1C is a tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations of CDKN1C are implicated in sporadic cancers and Beckwith-Wiedemann syndrome suggesting that it is a tumor suppressor candidate.
CDKN1C is a tumor suppressor human gene on chromosome 11 (11p15) and belongs to the cip/kip gene family. It encodes a cell cycle inhibitor that binds to G1 cyclin-CDK complexes. Thus p57KIP2 causes arrest of the cell cycle in G1 phase.
A mutation of this gene may lead to loss of control over the cell cycle leading to uncontrolled cellular proliferation. p57KIP2 has been associated with Beckwith-Wiedemann syndrome (BWS) which is characterized by increased risk of tumor formation in childhood. Loss-of-function mutations in this gene have also been shown associated to the IMAGe syndrome (Intrauterine growth restriction, Metaphyseal dysplasia, Adrenal hypoplasia congenita, and Genital anomalies).
P57 is an oxypregnane steroidal glycoside isolated from the African cactiform Hoodia gordonii. P57 is thought to be the main active constituent from this plant that may be responsible for the possible appetite suppressant activity of Hoodia extracts.
In a rat study at Brown Medical School, intracerebroventricular injections of the purified P57 demonstrated that the compound has a likely central nervous system (CNS) mechanism of action. The studies demonstrated that the compound increases the content of ATP by 50-150% in hypothalamic neurons. In addition, third ventricle administration of P57 reduced subsequent 24-hour food intake by 40-60%.
This is the way I live.
Lil' Boy still pushin' big wheels
I stack my money, lay low, and chill.
Don't need to work hard that's the way I feel, I feel, I
This is the way I live.
Lil' Boy still pushin' big wheels
I stack my money, lay low, and chill.
Don't need to work hard that's the way I feel, I feel, I
This is the way I live.
Six months later now we're big dog status.
Name elevated but I still act average.
Rockin' shows in Dallas, ball like I play for the Mavericks.
West Bank rapper and I'm one of the baddest.
French Rivera spot and I'm getting in shape man.
I think I'm Super M-a-n without a cape man.
Ridin' all day hustlin'; all for the cake man.
I'm a Benjamin stack one inch taller than Great Danes.
First they made cheap Ray-Ban like a felon.
I'm growin' up now spittin' hotter than Mohellans
I'm a steal every girl ever gon' to fly.
I'm a young little dude, stay runnin' from cops.
Emerald Row is the place where I got my props.
People love me in da hood they don't want me to stop.
So uhh, that's the only way I know how to rock.
And I'm a stay rappers like won't stop ‘til I drop.
This is the way I live.
Lil' Boy still pushin' big wheels
I stack my money, lay low, and chill.
Don't need to work hard that's the way I feel, I feel, I
This is the way I live.
Lil' Boy still pushin' big wheels
I stack my money, lay low, and chill.
Don't need to work hard that's the way I feel, I feel, I
This is the way I live.
I I's Baby Boy and I done it again.
I'm ridin fly with D-Wizzle in ‘cedes Benz
Twenty two wanna ride with the ladies then
Red Bull, Grey Goose, now the ladies bent
Now we go and do a thing under a shady tent
And they don't question what I say cause I'm a ladies pimp.
See this little one right here this fellow got stripes.
And I is represent, my rail room for life.
Money in my pocket but I still act trife
While I in da club they say the parlor a'int right.
Look I'm-doing great that's the way I feel.
Hustlin' hard all day that's the way I live.
This is the way I live.
Lil' Boy still pushin' big wheels
I stack my money, lay low, and chill.
Don't need to work hard that's the way I feel, I feel, I
This is the way I live.
Lil' Boy still pushin' big wheels
I stack my money, lay low, and chill.
Don't need to work hard that's the way I feel, I feel, I
This is the way I live.
This the two-seat rider with the ketchup inside.
Red pepper paint must believe my ish ride.
They pause like stop signs when they rollin' up.
Cause' when the doors open up, they open UP.
I'm Lamboin' it I was stashed, off stage I'm throwin' it.
Cause they say I'm like Katrina with money, I blow the shhhh.
Real been gravy, three years out of da eighties.
Solos, shabo's valley animals played it.
Commodores mirages, not the Nike hirages.
It cost 250 on up to put your foot inside this.
Y'all was wearing rocks that was my time to shine.
Don't give me viesels y'all thinkin' this McDonalds size.
I been fly I I I I I I I I from the crib to the ri I I I I I de
Fifty-Four inch screens 26 inches from the ceiling dude.
The plasma look like a projector up in da livin' room homie!
This is the way I live.
Lil' Boy still pushin' big wheels
I stack my money, lay low, and chill.
Don't need to work hard that's the way I feel, I feel, I
This is the way I live.
Lil' Boy still pushin' big wheels
I stack my money, lay low, and chill.
Don't need to work hard that's the way I feel, I feel, I