Evans Blue (dye)

T-1824 or Evans Blue, often incorrectly rendered as Evan's Blue, is an azo dye which has a very high affinity for serum albumin. Because of this, it can be useful in physiology in estimating the proportion of body water contained in blood plasma.

Evans blue dye has been used as a viability assay on the basis of its penetration into non-viable cells, although the method is subject to error because it assumes that damaged or otherwise altered cells are not capable of repair and therefore are not viable.

Evans blue is also used to assess the permeability of the blood–brain barrier to macromolecules. Because serum albumin cannot cross the barrier, and virtually all Evans Blue is bound to albumin, normally the neural tissue remains unstained. When the BBB has been compromised, albumin-bound Evans blue enters the CNS. It fluoresces with excitation peaks at 470 and 540 nm and an emission peak at 680 nm.

Evans blue is pharmacologically active, acting as a negative allosteric modulator of the AMPA and kainate receptors and as an inhibitor of vesicular glutamate transporters. It also acts on P2 receptors.

Evans Blue

Evans Blue is an alternative rock band from Toronto, Ontario, Canada founded in 2005. Altogether, they have sold over 1 million albums worldwide, including four studio albums and one live album.

History

Origins (2005)

Evans Blue came together in early 2005. Five musicians, then in three separate bands, met through a local musician's message board. Lead singer Kevin Matisyn suggested the name, which refers to the dye that is injected into the bloodstream to measure blood volume, which he had read in one of his medical books. The band then caught the attention of producer Trevor Kustiak (Cool for August) and his partner Mari Dew, of The Pocket Studios. The original lead guitarist, Kevin Smith, left due to personal reasons before the group secured a record label.

They recorded three demo songs, titled "Black Hole", "Saturnalia" and "Starlight", all of which were available on their personal MySpace page. At that time, updates on the bands' progress and prose by former lead singer, Kevin Matisyn were periodically given via the MySpace blogs.

Out There

Out There may refer to:

In music:

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In computing:

Out There (The Original Sins album)

Out There is the fifth studio album by garage rock band The Original Sins, released during the later half of 1992, only a couple of months after their previous release Move. It is the first album by the group to feature drummer Seth Baer.

Track listing

All songs written and composed by John Terlesky. 

Personnel

References

External links

Out There (Rick Wakeman album)

Out There is a progressive rock album released in 2003 by former Yes keyboardist Rick Wakeman. The album features a new version of The English Rock Ensemble. .

Track listing

+US reissue only

Personnel

Trivia

References