OTOF

Otoferlin is a protein that in humans is encoded by the OTOF gene.

Mutations in this gene are a cause of neurosensory nonsyndromic recessive deafness, DFNB9. The short form of the encoded protein has three C2 domains, a single carboxy-terminal transmembrane domain found also in the C. elegans spermatogenesis factor FER-1 and human dysferlin, while the long form has six C2 domains. The homology suggests that this protein may be involved in vesicle membrane fusion. Several transcript variants encoding multiple isoforms have been found for this gene.

References

External links

  • GeneReviews/NCBI/NIH/UW entry on OTOF-Related Deafness
  • Further reading


    Podcasts:

    PLAYLIST TIME:

    Girl Ridin' Shotgun

    by: Joe Diffie

    Whoa, she's a hot one
    It's a hot day, and I've got a pocketful of money
    Friday, tires roarin', you can hear me comin'
    Cooler in the back, Bud Light ice cold
    Me and my buddies cuttin' down an old back road
    I got a jacked up truck, but it ain't much
    A fixer upper with a brand new clutch
    Yeah, it takes me anywhere I wanna go even though
    It's hard for me to keep my eyes on the road
    But that girl ridin' in the shotgun
    Sunkissed by the Dixie hot sun
    Whoa, she's a hot one, yeah
    Aldean all up on the radio
    Dashboard lights shinin' on my baby, oh
    Later on, gonna have me a little fun
    With that girl ridin' shotgun, yeah
    Whoa, girl ridin' shotgun
    She's the girl of my dreams, she gives me everything
    Wearin' short shorts or some tight blue jeans
    She's country, and she ain't afraid to break a nail
    Raise hell, or go to jail, I keep her by my side
    She's always ready to ride, and sometimes
    She even drives when it's in four wheel drive
    Never known to back down from anything
    And you know she keeps her motor clean, yeah
    That girl ridin' shotgun
    Sunkissed by the Dixie hot sun
    Whoa, she's a hot one, yeah
    Aldean all up on the radio
    Dashboard lights shinin' on my baby, oh
    Later on, gonna have me a little fun
    With that girl ridin' shotgun, yeah
    Whoa, girl ridin' shotgun
    She could be the centerfold of "Field and Stream"
    Holdin' that double barrel twelve gauge
    To me, nothin' sweeter than a Georgia peach
    Playin' air guitar to a song I sang, a song I sang
    Talkin' 'bout
    That pretty little redneck girl ridin' shotgun
    Sunkissed by the Dixie hot sun
    Whoa, she's a hot one, yeah
    Aldean all up on the radio
    Dashboard lights shinin' on my baby, oh
    Later on, gonna have me a little fun
    With that girl ridin' shotgun, yeah
    Whoa, girl ridin' shotgun




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